| Identification | Back Directory | [Name]
Siltenzepine | [CAS]
98374-54-0 | [Synonyms]
Siltenzepine
8-Chlor-5,10-dihydro-5--11H-dibenzo<1,4>-diazepin-11-on
11H-Dibenzo[b,e][1,4]diazepin-11-one, 5-[2-[bis(2-hydroxyethyl)amino]acetyl]-8-chloro-5,10-dihydro- | [Molecular Formula]
C19H20ClN3O4 | [MDL Number]
MFCD00866742 | [MOL File]
98374-54-0.mol | [Molecular Weight]
389.83 |
| Hazard Information | Back Directory | [Uses]
Siltenzepine (AWD 26-06 free base) is an antagonist of mAChR with anti-acid activity, which can be used in peptic ulcers research. Siltenzepine exhibits rapidly but incompletely absorbed characterastic in rats (po)[1][2]. | [in vivo]
Siltenzepine (po) exhibits short distribution (t1/2 alpha=37 min) followed by a middle-long elimination (t1/2 beta=14 h) in rats[1]. | [References]
[1] Pfeifer S, et al. Biotransformation und Pharmakokinetik von AWD 26-06, 8-Chlor-5,10-dihydro-5-[bis(2-hydroxyethyl)aminoacetyl]-11H- dibenzo[d,c][1,4]diazepin-11-on-hydrochlorid an der Ratte [Biotransformation and pharmacokinetics of AWD 26-06, 8-chloro-5,10-dihydro-5-[bis(2-hydroxyethyl)aminoacetyl]-11H-dibenzo[d, c][1,4]diazepin-11-one hydrochloride in the rat]. Pharmazie. 1990 Jul;45(8):603-7. German. PMID:2080209
[2] Trausch B, et al. The biliary and renal elimination of the new muscarinic-1-antagonist AWD 26-06 in volunteers with T-tube after cholecystectomy. Int J Clin Pharmacol Ther Toxicol. 1992 Nov;30(11):508-9. PMID:1490811 |
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