| Identification | Back Directory | [Name]
L-Methioninamide, L-leucyl-L-seryl-L-tryptophyl-L-α-aspartyl-L-leucyl-L-prolyl-L-α-glutamyl-L-prolyl-L-arginyl-L-seryl-L-arginyl-L-alanylglycyl-L-lysyl-L-isoleucyl-L-arginyl-L-valyl-L-histidyl-L-prolyl-L-arginylglycyl-L-asparaginyl-L-leucyl-L-tryptophyl-L-alanyl-L-threonylglycyl-L-histidyl-L-phenylalanyl- | [CAS]
98537-35-0 | [Synonyms]
L-Methioninamide, L-leucyl-L-seryl-L-tryptophyl-L-α-aspartyl-L-leucyl-L-prolyl-L-α-glutamyl-L-prolyl-L-arginyl-L-seryl-L-arginyl-L-alanylglycyl-L-lysyl-L-isoleucyl-L-arginyl-L-valyl-L-histidyl-L-prolyl-L-arginylglycyl-L-asparaginyl-L-leucyl-L-tryptophyl-L-alanyl-L-threonylglycyl-L-histidyl-L-phenyla...
L-Methioninamide, L-leucyl-L-seryl-L-tryptophyl-L-α-aspartyl-L-leucyl-L-prolyl-L-α-glutamyl-L-prolyl-L-arginyl-L-seryl-L-arginyl-L-alanylglycyl-L-lysyl-L-isoleucyl-L-arginyl-L-valyl-L-histidyl-L-prolyl-L-arginylglycyl-L-asparaginyl-L-leucyl-L-tryptophyl-L-alanyl-L-threonylglycyl-L-histidyl-L-phenylalanyl- | [Molecular Formula]
C157H243N51O38S | [MOL File]
98537-35-0.mol | [Molecular Weight]
3484.99 |
| Chemical Properties | Back Directory | [density ]
1.50±0.1 g/cm3(Predicted) | [Sequence]
Leu-Ser-Trp-Asp-Leu-Pro-Glu-Pro-Arg-Ser-Arg-Ala-Gly-Lys-Ile-Arg-Val-His-Pro-Arg-Gly-Asn-Leu-Trp-Ala-Thr-Gly-His-Phe-Met-NH2 |
| Hazard Information | Back Directory | [Uses]
Neuromedin B-30 is the neuropeptide, which is orignally isolated from porcine brain and spinal cord. , and may exhibit activity in stimulating smooth-muscle. Neuromedin B causes local vasodilation, increases vascular permeability and local hyperalgesia, thereby participating in neurogenic inflammation. Neuromedin B regulates appetite, body temperature, and behavioral responses to stress. Neuromedin B is also involved in regulating smooth muscle contraction and secretory function in the gastrointestinal tract[1][2][3]. | [References]
[1] Minamino N, et al., Neuromedins: novel smooth-muscle stimulating peptides identified in porcine spinal cord. Peptides. 1985;6 Suppl 3:245-8. DOI:10.1016/0196-9781(85)90381-x
[2] Minamino N, et al., Neuromedin B-32 and B-30: two "big" neuromedin B identified in porcine brain and spinal cord. Biochem Biophys Res Commun. 1985 Jul 31;130(2):685-91. DOI:10.1016/0006-291x(85)90471-1
[3] Mishra SK, et al., A nociceptive signaling role for neuromedin B. J Neurosci. 2012 Jun 20;32(25):8686-95. DOI:10.1523/JNEUROSCI.1533-12.2012 |
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