| Identification | Back Directory | [Name]
Stacofylline | [CAS]
98833-92-2 | [Synonyms]
Stacofylline
1,3,7-trimethyl-8-[3-(4-diethylaminocarbonyl-piperazino) propyl] xanthine
1-Piperazinecarboxamide, N,N-diethyl-4-[3-(2,3,6,7-tetrahydro-1,3,7-trimethyl-2,6-dioxo-1H-purin-8-yl)propyl]- | [Molecular Formula]
C20H33N7O3 | [MDL Number]
MFCD09838133 | [MOL File]
98833-92-2.mol | [Molecular Weight]
419.52 |
| Hazard Information | Back Directory | [Uses]
Stacofylline (S 9977 free base; S 9977-2 free base) a xanthine derivative, is a potent AChE inhibitor with an IC50 of 5-50 nM. Stacofylline shows anti-amnesic and promnesic activities[1]. | [in vivo]
In Scopolamine, Diazepam, and electroconvulsive shock (ECS) mouse models, Stacofylline (S 9977) at low doses (0.0312-0.5 mg/kg; p.o.) clearly attenuates the memory deficits induced by the three amnesic treatments after acute treatment[2]. | [References]
[1] L E Trudeau, et al. Xanthine derivatives IBMX and S-9977-2 potentiate transmission at an Aplysia central cholinergic synapse. Brain Res. 1992 Jul 17;586(1):78-85. DOI:10.1016/0006-8993(92)91374-n
[2] Roger D. Porsolt, et al. Potential cognition-enhancing properties of S 9977 in three moenls of amnesia in the mouse. Drug Development Research. 1992. |
|
|