| Identification | Back Directory | [Name]
epidermin | [CAS]
99165-17-0 | [Synonyms]
epidermin
PubChem ID: 16132391
L-Cysteinamide, L-isoleucyl-L-alanyl-D-cysteinyl-L-lysyl-L-phenylalanyl-L-isoleucyl-L-cysteinyl-(2S,3S)-2-amino-3-mercaptobutanoyl-L-prolylglycyl-L-cysteinyl-L-alanyl-L-lysyl-(2Z)-2-amino-2-butenoylglycyl-D-cysteinyl-L-phenylalanyl-L-asparaginyl-D-cysteinyl-L-tyrosyl-N-[(1Z)-2-mercaptoethenyl]-, cyc... | [Molecular Formula]
C98H141N25O23S4 | [MOL File]
99165-17-0.mol | [Molecular Weight]
2165.58 |
| Hazard Information | Back Directory | [Description]
Epidermin is defined as a lantibiotic produced by S. epidermidis, which is a thioether amino acid–containing antimicrobial peptide active against various bacteria, contributing to bacterial interference and colonization on human skin.
| [Synthesis]
Solid-phase peptide synthesis of epidermin:epidermin is synthesized in the ribosome via a precursor protein, followed by enzymatic modifications. It was isolated from the culture filtrate of Staphylococcus epidermidis TU 3298 by adsorption on Amberlite XAD-8. The basic heneicosapeptide amide was chromatographed on Sephadex LH-20 and purified to homogeneity via multiplicative counter-current distributions in one acidic and one neutral system.
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