| Identification | Back Directory | [Name]
CKS 17 | [CAS]
99273-04-8 | [Synonyms]
Aids002113
Aids-002113
Lqnrrgldllflkeggl-bsa
CKS-17 H-Leu-Gln-Asn-Arg-Arg-Gly-Leu-Asp-Leu-Leu-Phe-Leu-Lys-Glu-Gly-Gly-Leu-OH
Leu-Gln-Asn-Arg-arg-Gly-Leu-Asp-Leu-leu-Phe-Leu-Lys-Glu-Gly-gly-Leu linked to bsa
L-Leucyl-L-glutaminyl-L-asparaginyl-L-arginyl-L-arginylglycyl-L-leucyl-L-α-aspartyl-L-leucyl-L-leucyl-L-phenylalanyl-L-leucyl-L-lysyl-L-α-glutamylglycylglycyl-L-leucine
L-Leucine, L-leucyl-L-glutaminyl-L-asparaginyl-L-arginyl-L-arginylglycyl-L-leucyl-L-α-aspartyl-L-leucyl-L-leucyl-L-phenylalanyl-L-leucyl-L-lysyl-L-α-glutamylglycylglycyl-
L-Leucine, L-leucyl-L-glutaminyl-L-asparaginyl-L-arginyl-L-arginylglycyl-L-leucyl-L-.alpha.-aspartyl-L-leucyl-L-leucyl-L-phenylalanyl-L-leucyl-L-lysyl-L-.alpha.-glutamylglycylglycyl- | [Molecular Formula]
C87H148N26O24 | [MOL File]
99273-04-8.mol | [Molecular Weight]
1942.28 |
| Hazard Information | Back Directory | [Uses]
CKS-17 is a synthetic retroviral envelope peptide. CKS-17 has the highly conserved amino acid sequences occurring within the transmembrane envelope protein of many animal and human retroviruses. CKS-17 acts as an immunomodulatory epitope and exhibits suppressive properties for numerous immune functions[1][2][3]. | [in vivo]
CKS-17 (10 μM; i.d.; B6AF1 mice and C57BL/6J mice) inhibits delayed-type hypersensitivity (DTH) reactions to sheep erythrocytes in the feet of mice[2]. | Animal Model: | B6AF1 mice and C57BL/6J mice with DTH models[2] | | Dosage: | 10 μM | | Administration: | Intradermal injection, into the right hind footpad | | Result: | Had a transient depressive effect on DTH reaction. |
| [References]
[1] Haraguchi S, et, al. Induction of intracellular cAMP by a synthetic retroviral envelope peptide: a possible mechanism of immunopathogenesis in retroviral infections. Proc Natl Acad Sci U S A. 1995 Jun 6;92(12):5568-71. DOI:10.1073/pnas.92.12.5568
[2] Nelson M, et, al. Effects of CKS-17, a synthetic retroviral envelope peptide, on cell-mediated immunity in vivo: immunosuppression, immunogenicity, and relation to immunosuppressive tumor products. Cancer Immunol Immunother. 1989;30(2):113-8. DOI:10.1007/BF01665962
[3] Nelson M, et, al. Inhibition of interleukin-2 production by tumor cell products and by CKS-17, a synthetic retroviral envelope peptide. Cancer Immunol Immunother. 1990;30(6):331-41. DOI:10.1007/BF01786882 |
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cjbscvictory
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13348960310 13348960310 |
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www.weikeqi-biotech.com/ |
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