| Identification | Back Directory | [Name]
HUMAN NEUTROPHIL PEPTIDE-1 | [CAS]
99287-08-8 | [Synonyms]
HNP-1
HUMAN NP-1
HUMAN HNP-1
NP-1, HUMAN
BD-1, HUMAN
HNP-1 (HUMAN)
HUMAN CRYPTDIN
alpha Defensin-1
DEFENSIN-1, HUMAN
α-Defensin-1, human
neutrophil peptide-1
DEFENSIN HNP-1 (HUMAN)
HUMAN ALPHA-DEFENSIN-1
RECOMBINANT HUMAN NP-1
ALPHA-DEFENSIN-1, HUMAN
DEFENSIN-1, ALPHA-, HUMAN
HUMAN NEUTROPHIL PEPTIDE-1
DEFENSIN HUMAN NEUTROPHIL PEPTIDE-1
HNP-1, Defensin Human Neutrophil Peptide-1
ACYCRIPACIAGERRYGTCIYQGRLWAFCC (DISULFIDE BRIDGE: 2-30,4-19,9-29)
ALA-CYS-TYR-CYS-ARG-ILE-PRO-ALA-CYS-ILE-ALA-GLY-GLU-ARG-ARG-TYR-GLY-THR-CYS-ILE-TYR-GLN-GLY-ARG-LEU-TRP-ALA-PHE-CYS-CYS
H-ALA-CYS-TYR-CYS-ARG-ILE-PRO-ALA-CYS-ILE-ALA-GLY-GLU-ARG-ARG-TYR-GLY-THR-CYS-ILE-TYR-GLN-GLY-ARG-LEU-TRP-ALA-PHE-CYS-CYS-OH
H-ALA-CYS-TYR-CYS-ARG-ILE-PRO-ALA-CYS-ILE-ALA-GLY-GLU-ARG-ARG-TYR-GLY-THR-CYS-ILE-TYR-GLN-GLY-ARG-LEU-TRP-ALA-PHE-CYS-CYS-OH (DISULFIDE BRIDGE: 2-30, 4-19, 9-29)
ASP-HIS-TYR-ASN-CYS-VAL-SER-SER-GLY-GLY-GLN-CYS-LEU-TYR-SER-ALA-CYS-PRO-ILE-PHE-THR-LYS-ILE-GLN-GLY-THR-CYS-TYR-ARG-GLY-LYS-ALA-LYS-CYS-CYS-LYS (DISULFIDE BRIDGE: CYS5- CYS34, CYS12-CYS27, CYS17-CYS35)
L-Cysteine, L-alanyl-L-cysteinyl-L-tyrosyl-L-cysteinyl-L-arginyl-L-isoleucyl-L-prolyl-L-alanyl-L-cysteinyl-L-isoleucyl-L-alanylglycyl-L-α-glutamyl-L-arginyl-L-arginyl-L-tyrosylglycyl-L-threonyl-L-cysteinyl-L-isoleucyl-L-tyrosyl-L-glutaminylglycyl-L-arginyl-L-leucyl-L-tryptophyl-L-alanyl-L-phenylalan... | [Molecular Formula]
C150H228N44O38S6 | [MDL Number]
MFCD00214572 | [MOL File]
99287-08-8.mol | [Molecular Weight]
3448.08 |
| Chemical Properties | Back Directory | [density ]
1.50±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [storage temp. ]
-20°C | [solubility ]
water: soluble1mg/mL, clear, colorless | [form ]
Solid | [color ]
white to off-white | [biological source]
human | [Water Solubility ]
water: 1mg/mL, clear, colorless | [InChIKey]
KRJOFJHOZZPBKI-KSWODRSDSA-N |
| Hazard Information | Back Directory | [Uses]
The α-defensin genes, such as DEFA1 (defensin alpha 1) and DEFA3 (defensin α 3) codes for HNP-1, 2 and 3 (human neutrophil peptides). This gene is mapped to human chromosome 8p23.1.
Chemical structure: peptide | [General Description]
Chemical structure: peptide | [Biochem/physiol Actions]
Human neutrophil peptides (HNPs) is involved in endothelial cell dysfunction at the time of early atherosclerotic development.?HNP 1?3 can regulate the growth of atherosclerosis. HNP 1?3 levels are usually high in inflammation, including sepsis and acute coronary vascular disorders. |
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Sigma-Aldrich
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https://www.sigmaaldrich.cn |
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