| Identification | Back Directory | [Name]
7-BROMO-2-METHOXYQUINOLINE | [CAS]
99455-08-0 | [Synonyms]
7-BROMO-2-METHOXYQUINOLINE
Quinoline, 7-bromo-2-methoxy- | [Molecular Formula]
C10H8BrNO | [MDL Number]
MFCD11877930 | [MOL File]
99455-08-0.mol | [Molecular Weight]
238.08 |
| Chemical Properties | Back Directory | [Melting point ]
68 °C | [Boiling point ]
312.6±22.0 °C(Predicted) | [density ]
1.516±0.06 g/cm3(Predicted) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2-8°C | [pka]
1.62±0.50(Predicted) | [Appearance]
White to light brown Solid |
| Hazard Information | Back Directory | [Synthesis]
7-Bromo-2-chloroquinoline (2) was used as starting material and reacted with sodium methanol to prepare 7-bromo-2-methoxyquinoline (1) in 98% yield. The melting point of the product was 68-69 °C. The nuclear magnetic resonance hydrogen spectrum (1H NMR, 300 MHz, CDCl3) data were as follows: δ 8.05 (d, 1H, J = 1.8 Hz), 7.93 (d, 1H, J = 8.7 Hz), 7.57 (d, 1H, J = 9.0 Hz), 7.47 (dd, 1H, J = 8.7 Hz, 1.8 Hz), 6.91 (d, 1H, J = 9.0 Hz), 4.00 (s, 3H). The mass spectrum (MS, APCI, pos. 30V) showed a molecular ion peak m/z of 239.06 ([M + H]+). | [References]
[1] European Journal of Medicinal Chemistry, 2010, vol. 45, # 4, p. 1657 - 1662
[2] European Journal of Medicinal Chemistry, 2017, vol. 127, p. 621 - 631
[3] Journal of Medicinal Chemistry, 1988, vol. 31, # 10, p. 2048 - 2056 |
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| Company Name: |
Cool Pharm, Ltd
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021-60455363 18019463053 |
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www.coolpharm.com |
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