| Identification | Back Directory | [Name]
3-BOC-AMINO-PYRROLIDIN-2-ONE | [CAS]
99780-97-9 | [Synonyms]
3-BOC-AMINO-PYRROLIDIN-2-ONE
tert-Butyl (2-oxopyrrolidin-3-yl)
tert-butyl N-(2-oxopyrrolidin-3-yl)carbamate
Carbamic acid, N-(2-oxo-3-pyrrolidinyl)-, 1,1-dimethylethyl ester | [Molecular Formula]
C9H16N2O3 | [MDL Number]
MFCD11007813 | [MOL File]
99780-97-9.mol | [Molecular Weight]
200.23 |
| Chemical Properties | Back Directory | [Boiling point ]
394.0±31.0 °C(Predicted) | [density ]
1.13±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [pka]
11.05±0.20(Predicted) | [Appearance]
White to off-white Solid |
| Hazard Information | Back Directory | [Synthesis]
To a mixed methanol and triethylamine solution (9:1, 130 mL, v/v) of 3-aminopyrrolidin-2-one (39) (2.8 g, 28 mmol), di-tert-butyl dicarbonate (6.7 g, 30.8 mmol) was added. The reaction mixture was stirred overnight at room temperature and then heated to reflux for 2 hours. After completion of the reaction, the solvent was removed by distillation under reduced pressure and the resulting solid was collected by filtration and washed with ether to afford 3-(Boc-amino)pyrrolidin-2-one in 97% yield. | [References]
[1] Patent: US2005/165065, 2005, A1. Location in patent: Page/Page column 24
[2] Patent: WO2017/75056, 2017, A1. Location in patent: Paragraph 0371
[3] Journal of Medicinal Chemistry, 1986, vol. 29, # 2, p. 251 - 260
[4] Patent: US6441017, 2002, B1 |
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