| Identification | Back Directory | [Name]
SM 2470 | [CAS]
99899-45-3 | [Synonyms]
SM 2470
[4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-(5-bicyclo[2.2.2]oct-2-enyl)methanone | [Molecular Formula]
C23H30ClN5O3 | [MOL File]
99899-45-3.mol | [Molecular Weight]
459.98 |
| Hazard Information | Back Directory | [Uses]
SM-2470 is a potent α1-adrenoceptor antagonist, has sympathetic nerve activity in anesthetized rats[1]. SM-2470 is an antihypertensive agent. SM-2470 exhibits hypocholesterolaemic effect by the inhibition of cholesterol absorption related to the reduction of cholesterol solubilization[2]. | [IC 50]
α adrenergic receptor | [References]
[1] M Yoshioka, et al. Effect of SM-2470, a newly synthetized alpha 1-adrenoceptor antagonist, on sympathetic nerve activity in anesthetized rats. Arch Int Pharmacodyn Ther. May-Jun 1988;293:162-74. PMID:2901824 |
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