1001600-56-1

中文名称 BV 6

英文名称 BV6

CAS 1001600-56-1

分子式 C70H96N10O8.xCF3COOH

分子量 1205.57

MOL 文件 1001600-56-1.mol

更新日期 2024/01/31 11:06:36

1001600-56-1 结构式

基本信息物理化学性质安全数据常见问题列表图谱信息

基本信息

中文别名

化合物BV6
BV-6游离态

英文别名

BV6
CS-1501
CS-2877
BV-6
BV6
BV-6 TFA
CHEBI:47924
BV6 USP/EP/BP
CHEBI:47924
BV-6 BV 6
4,4'-(1,6-Hexanediyl)bis[N-methyl-L-alanyl-(2S)-2-cyclohexylglycyl-L-prolyl-β-phenyl-L-Phenylalanin
L-Phenylalaninamide, 4,4'-(1,6-hexanediyl)bis[N-methyl-L-alanyl-(2S)-2-cyclohexylglycyl-L-prolyl-β-phenyl-

所属类别

生物化工：IAP 抑制剂

物理化学性质

沸点1376.7±65.0 °C(Predicted)

密度1.177±0.06 g/cm3(Predicted)

储存条件Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

溶解度≥60.28 mg/mL in DMSO; insoluble in H2O; ≥12.6 mg/mL in EtOH with ultrasonic

酸度系数(pKa)12.89±0.20(Predicted)

形态固体

安全数据

危险性符号(GHS)

GHS07

警示词警告

危险性描述H302-H315-H319-H335

防范说明P261-P305+P351+P338

常见问题列表

生物活性

BV-6是一种SMAC模拟的cIAP和XIAP的双重抑制剂。

体外研究

BV6抑制HCC193 NSCLC细胞的细胞活性，IC50 为 7.2 μM，在HCC193 和H460细胞系引起细胞凋亡，并通过分别激活裂解的caspase-8 和caspase-9显著增加这些细胞系的放射敏感性。在不成熟的树突细胞中，BV-6治疗导致经典的NF-kB通路适度激活。此外，BV-6增加CIK细胞介导的血液病(H9，THP-1，和Tanoue)和固体肿瘤(RH1，RH30，和TE671)的消退。BV-6也会增强外周血单核细胞的凋亡，并且对免疫细胞限制其细胞毒性潜能具有显著的抑制作用。

靶点

IAP

体内研究

Murine cIAP-1, cIAP-2 and XIAP expressions are clearly observed in the cytoplasm of both epithelial and stromal cells of implants, whereas Survivin is mainly expressed in the nuclei BV6 treatment for 4 weeks attenuated the intensity of IAPs expression. The size of lesions range from ~2 to 7 mm in diameter. The monolayer epithelial cell lining of the cyst is shown. After immunohistochemical staining, cytokeratin and vimentin are positively stained, whereas calretinin is negative. After BV6 treatment for 4 weeks, the total number of lesions (4.6 versus 2.8/mouse), the average weight (78.1 versus 32.0 mg/mouse) and the surface area (44.5 versus 24.6 mm ² /mouse) of lesions are significantly less than in the controls. In the endometrial gland epithelia or stroma, the percentage of Ki67-positive cells decreases after BV6 treatment.

图谱信息

BV 6(1001600-56-1)质谱(MS)