103404-90-6
103404-90-6 结构式
基本信息
D-A-羟基戊二酸二钠
2-羟基-D-谷氨酸钠
D-Α-羟基戊二酸二钠盐
(R)-2-羟基戊二酸钠
D-2-羟基戊二酸 二钠盐
(R)-2-羟基戊二酸二钠盐
2-羟基-D-谷氨酸 二钠盐
(R)-2-羟基戊二酸二钠盐, D-A-羟基戊二酸二钠
D-2-HYDROXYPENTANEDIOIC ACID鈥NA+
(r)-2-hydroxypentanedioic acid
Disodium (R)-2-hydroxyglutarate
(2R)-2-Hydroxypentanedioic acid
D-A-HYDROXYGLUTARIC ACID DISODIUM
SodiuM (R)-2-hydroxypentanedioate
D-α-Hydroxyglutaric acid disodium
isodium,(2R)-2-hydroxypentanedioate
D-ALPHA-HYDROXYGLUTARIC ACID DISODIU
disodium:(2R)-2-hydroxypentanedioate
物理化学性质
常见问题列表
| Target | Value |
| α-ketoglutarate-dependent dioxygenase |
在U-87MG细胞中，(R)-2-Hydroxyglutarate作为α-KG的弱拮抗剂抑制α-KG依赖性组蛋白脱甲基化酶，并增加H3K9和H3K79的二甲基化作用。此外，(R)-2-Hydroxyglutarate抑制ATP合酶与mTOR信号，因此引起生长阻滞和肿瘤细胞杀伤。
D-α-Hydroxyglutaric acid strongly inhibits glucose utilization, CO
2
production and the respiratory chain in rat cerebral cortex and human skeletal muscle, as well as in submitochondrial particles from bovine heart, suggesting an impairment of the aerobic metabolism.
D-α-Hydroxyglutaric acid has also been proposed as an endogenous excitotoxic organic acid because it significantly decreased cell viability in neuronal cultures from chick embryo telencephalons and from neonatal rat hippocampus through stimulation of specific NMDA glutamate receptors.
D-α-Hydroxyglutaric acid (0.01-1 mM) significantly increases chemiluminescence and thiobarbituric acid-reactive substances (TBA-RS) and decreased total antioxidant reactivity (TAR) values in the cortical supernatants in 30-day-old-rats.