| Identification | Back Directory | [Name]
D-2-HYDROXYPENTANEDIOIC ACID DISODIUM SALT | [CAS]
103404-90-6 | [Synonyms]
sodiuM 2-hydroxypentanedioate
(r)-2-hydroxypentanedioic acid
Disodium (R)-2-hydroxyglutarate
(2R)-2-Hydroxypentanedioic acid
D-α-Hydroxyglutaric acid disodium
SodiuM (R)-2-hydroxypentanedioate
D-A-HYDROXYGLUTARIC ACID DISODIUM
isodium,(2R)-2-hydroxypentanedioate
disodium:(2R)-2-hydroxypentanedioate
D-ALPHA-HYDROXYGLUTARIC ACID DISODIU
D-alpha-Hydroxyglutaric Acid Disodium
D-α-Hydroxyglutaric Acid (sodium salt)
d-α-hydroxyglutaric acid disodium salt
(2R)-2-Hydroxyglutaric Acid Disodium Salt
D-2-HYDROXYPENTANEDIOIC ACID DISODIUM SALT
D-ALPHA-HYDROXYGLUTARIC ACID DISODIUM SALT
D-.alpha.-Hydroxyglutaric Acid (sodium salt)
D-α-Hydroxyglutaric acid disodiuM salt
D-α-Hydroxypentanedioic acid disodium salt, 95%
Pentanedioic acid,2-hydroxy-, disodium salt, (2R)-
D-2-HYDROXYPENTANEDIOIC ACID DISODIUM SALT USP/EP/BP
D-alpha-Hydroxyglutaric acid disodiuM salt >=95% (GC) | [Molecular Formula]
C5H6Na2O5 | [MDL Number]
MFCD00069573 | [MOL File]
103404-90-6.mol | [Molecular Weight]
192.08 |
| Chemical Properties | Back Directory | [Melting point ]
>291°C (dec.) | [storage temp. ]
-20°C | [solubility ]
PBS (pH 7.2): 10 mg/ml | [form ]
A crystalline solid | [optical activity]
[α]/D 8.5±1.5°, c = 1 in NaOH | [Water Solubility ]
Soluble to 100 mM in water | [BRN ]
5318041 | [Stability:]
Hygroscopic | [InChIKey]
DZHFTEDSQFPDPP-HWYNEVGZSA-L |
| Hazard Information | Back Directory | [Description]
D-α-Hydroxyglutaric Acid (D-2-HG) is an α-hydroxy acid that is over-produced in the human neurometabolic disease D-2-hydroxyglutaric aciduria (D-2-HGA).1 It is normally synthesized from 2-ketoglutarate (2-KG) by hydroxyacid-oxoacid transhydrogenase (HOT), although defects in HOT are not known to be associated with D-2-HGA.1 Instead, type I D-2-HGA involves mutations in D-2-hydroxyglutarate dehydrogenase, which converts D-2-HG back to 2-KG.1 Type II D-2-HGA results from gain-of-function mutations in isocitrate dehydrogenase 2, causing it to supplement HOT in converting 2-KG to D-2-HG.2,3 In bacteria, this α-hydroxy acid may be synthesized from oxalate and propionyl-coenzyme A by an α-hydroxyglutaric acid synthetase.4 | [Chemical Properties]
Pale Orange Solid | [Uses]
A potential inhibitor of glutamate carboxypeptidase. | [Biochem/physiol Actions]
Biomarker for inborn errors of metabolism and cancer | [storage]
Store at -20°C |
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