1035979-44-2
中文名称
(4S,4AS,5AR,12AS)-4-(二甲基氨基)-1,4,4A,5,5A,6,11,12A-八氢-3,10,12,12A-四羟基-7-[(甲氧基甲基氨基)甲基]-1,11-二氧代-2-并四苯甲酰胺盐酸盐
英文名称
P005672 hydrochloride
CAS
1035979-44-2
分子式
C24H30ClN3O8
分子量
523.963
MOL 文件
1035979-44-2.mol
更新日期
2024/04/28 11:55:51
1035979-44-2 结构式
基本信息
中文别名
沙雷霉素盐酸沙林霉素
米诺环素杂质14
麦芽糖醇杂质14
(4S,4AS,5AR,12AS)-4-(二甲基氨基)-1,4,4A,5,5A,6,11,12A-八氢-3,10,12,12A-四羟基-7-[(甲氧基甲基氨基)甲基]-1,11-二氧代-2-并四苯甲酰
(4S,4AS,5AR,12AS)-4-(二甲基氨基)-1,4,4A,5,5A,6,11,12A-八氢-3,10,12,12A-四羟基-7-[(甲氧基甲基氨基)甲基]-1,11-二氧代-2-并四苯甲酰胺盐酸盐
英文别名
CS-267P005672
PO05672
P005672 HCl
Sarecycline
PO05672 HCl
Sarecycline HCl
P0-05672
P0 05672
Sarecycline(P005672)
Minocycline Impurity 14
所属类别
生物化工：激动剂抑制剂
常见问题列表
生物活性
Sarecycline hydrochloride 是一种窄谱四环素类抗生素。Sarecycline hydrochloride 具有抗炎作用和对革兰氏阳性菌的有效活性，包括对多种痤疮角质杆菌的活性。Sarecycline hydrochloride 干扰 tRNA 调节并将 mRNA 与 70S 核糖体结合。体外研究
Sarecycline inhibits 55 clinical isolates of
C. acnes
, and the MIC values for Sarecycline ranged from 0.5 to 16 µg/ml; the MIC
50
was 0.5 µg/ml, and the MIC
90
was 4 µg/ml. Sarecycline, exhibits activity against the macrolide-resistant organisms.
Sarecycline hydrochloride exhibits minimal activity against enteric aerobic Gram-negative bacteria.
体内研究
Sarecycline hydrochloride (0.33-9 mg/kg; i.v.) show potent activity against S. aureus in a murine neutropenic thigh infection model.
| Animal Model: | Female SD-1 mice (A murine neutropenic thigh wound infection model) |
| Dosage: | 0.33, 1, 3, or 9 mg/kg |
| Administration: | Intravenously |
| Result: | Achieved a 2-log10 reduction in the bacterial burden in the thigh at a dose comparable to that of doxycycline, with ED50s of 8.23 and 8.32 mg/kg, respectively. |