10477-72-2
10477-72-2 结构式
基本信息
中文别名
苯乙酸芥末苯芥-D3
苯乙酸芥末-D8
英文别名
CB-1331phenacid
NSC-71964
Phenylacetic acid mustard
Phenylacetic acid Mustard-d8
p-[Bis(2-chloroethyl)amino]phenylacetic acid
4-[Bis(2-chloroethyl)amino]benzeneacetic acid
2-[4-[bis(2-chloroethyl)amino]phenyl]acetic acid
物理化学性质
熔点105 °C(Solv: benzene (71-43-2); pentane (109-66-0))
沸点125°C (rough estimate)
密度1.2884 (rough estimate)
折射率1.6070 (estimate)
酸度系数(pKa)3.86±0.10(Predicted)
常见问题列表
生物活性
Phenylacetic acid mustard 是化疗试剂 Chlorambucil (HY-13593) 的主要代谢产物 (metabolite)。Chlorambucil 是一种烷化剂 (alkylator)，具有抗肿瘤活性。靶点
IC50: metabolite of Chlorambucil
体内研究
Phenylacetic acid mustard (intraperitoneal injection; 0-20 mg/kg; 15 days) shows consistently 1.8-1.9 times greater antitumour potency than CHL, it exhibits an ED 15 value of 8.0 mg/kg.Phenylacetic acid mustard (intraperitoneal injection; 0-20 mg/kg; single dose) cause 50% lethality at the dose 15.9 mg/kg.
| Animal Model: | Inbred male C3H/He mice |
| Dosage: | 0 mg/kg; 5 mg/kg; 10 mg/kg; 20 mg/kg |
| Administration: | Intraperitoneal injection; 15 days |
| Result: | Exhibited anti-tumor activities in vivo. |