| Identification | Back Directory | [Name]
phenacid | [CAS]
10477-72-2 | [Synonyms]
CB-1331
phenacid
NSC-71964
Phenylacetic acid mustard
Phenylacetic acid Mustard-d8
p-[Bis(2-chloroethyl)amino]phenylacetic acid
4-[Bis(2-chloroethyl)amino]benzeneacetic acid
2-[4-[bis(2-chloroethyl)amino]phenyl]acetic acid | [Molecular Formula]
C12H15Cl2NO2 | [MDL Number]
MFCD00444492 | [MOL File]
10477-72-2.mol | [Molecular Weight]
276.16 |
| Chemical Properties | Back Directory | [Melting point ]
105 °C(Solv: benzene (71-43-2); pentane (109-66-0)) | [Boiling point ]
125°C (rough estimate) | [density ]
1.2884 (rough estimate) | [refractive index ]
1.6070 (estimate) | [pka]
3.86±0.10(Predicted) |
| Hazard Information | Back Directory | [Uses]
Phenylacetic Mustard is a nitrogen mustard analog and the active metabolite of Chlorambucil (C325050). It is used as a chemotherapeutic agent and aside from having clastogenic activity, it can also induce chromosome delay. | [Safety Profile]
Poison by intraperitoneal route. Experimental reproductive effects. Mutation data reported. Whenheated to decomposition it emits toxic fumes of Clí and NOx. | [in vivo]
Phenylacetic acid mustard (intraperitoneal?injection; 0-20 mg/kg; 15 days) shows consistently 1.8-1.9 times greater antitumour potency than
CHL, it exhibits an ED15 value of 8.0 mg/kg[2].Phenylacetic acid mustard (intraperitoneal?injection; 0-20 mg/kg; single dose) cause 50% lethality at the dose 15.9 mg/kg[2]. | Animal Model: | Inbred male C3H/He mice[1] | | Dosage: | 0 mg/kg; 5 mg/kg; 10 mg/kg; 20 mg/kg | | Administration: | Intraperitoneal?injection; 15 days | | Result: | Exhibited anti-tumor activities in vivo. |
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BOC Sciences
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Energy Chemical
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Pharma Affiliates
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