105650-23-5
中文名称
2-氨基-1-甲基-6-苯基咪唑[4,5-b]吡啶
英文名称
2-AMINO-1-METHYL-6-PHENYLIMIDAZO[4,5-B]PYRIDINE
CAS
105650-23-5
分子式
C13H12N4
MDL 编号
MFCD00210745
分子量
224.26
MOL 文件
105650-23-5.mol
105650-23-5 结构式
基本信息
中文别名
2-氨基-1-甲基-6-苯基咪唑[4,5-b]吡啶 英文别名
2-AMINO-1-METHYL-6-PHENYLIMIDAZO[4,5-B]PYRIDINEPHIP
5-b)pyridin-2-amine,1-methyl-6-phenyl-1h-imidazo(
5-b)pyridine,2-amino-1-methyl-6-phenyl-1h-imidazo(
5-b)pyridine,2-amino-1-methyl-6-phenyl-imidazo(
Amino-1-methyl-6-phenylimidazo[4.5-b]pyridine
1-Methyl-6-phenyl-1H-imidazo[4,5-b]pyridin-2-amine
2-AMINO-1-METHYL-6-PHENYLIMADAZO(4,5-B)PYRIDINE
2-AMINO-1-METHYL-6-PHENYL-1H-IMIDAZO[4,5-B]PYRIDINE
2-AMINO-1-METHYL-6-PHENOLIMIDAZO[4,5-B]PYRIDINE
2-Amino-1-methyl-6-phenylimidazo[4,5,b]pyridine, (PhIP)
1-Methyl-6-phenyl-1H-imidazo[4,5-β]pyridin-2-amine
2-Amino-1-methyl-6-phenylimidazo[4,5-β]pyridine
物理化学性质
熔点300
沸点355.66°C (rough estimate)
密度1.2067 (rough estimate)
折射率1.5890 (estimate)
储存条件Refrigerator
溶解度DMF: 10 mg/ml; DMSO: 10 mg/ml; Ethanol: 15 mg/ml; Ethanol:PBS (pH 7.2) (1:3): 0.25 mg/ml
酸度系数(pKa)7.72±0.30(Predicted)
形态结晶固体
(IARC)致癌物分类2B (Vol. 56) 1993
常见问题列表
生物活性
PhIP 是在熟肉中形成的杂环芳香胺 (HAA)，是一种可能的致癌物。具有 DNA 破坏性和诱变性。 PhIP 还具有雌激素活性，可能有助于其组织特异性致癌性。体外研究
PhIP causes widespread and largely over-lapping effects on miRNA expression. PhIP induces widespread effects via activation of oestrogen receptor alpha (ERα). Deregulation of miRNA by PhIP could potentially be an important non-DNA-damaging carcinogenic mechanism in breast cancer.
体内研究
In hCYP1A-mice, PhIP induces inflammation, epithelial cell damage, and prostatic intraepithelial neoplasia in the dorsolateral prostate lobe compared to the ventral lobe. PhIP forms DNA adducts in the prostate, PhIP also induces oxidative stress, atrophy of the acini, and inflammation of the prostate of rodents.