106861-44-3
中文名称
米库氯铵
英文名称
Mivacurium chloride
CAS
106861-44-3
分子式
C58H80Cl2N2O14
分子量
1100.17
MOL 文件
106861-44-3.mol
更新日期
2024/09/19 10:38:09
106861-44-3 结构式
基本信息
中文别名
氯米洼库咪伐氯铵
米伐氯铵
米库氯铵
米库氯铵氯化物
-1,2,3,4-四氢-2-(3-羟丙基)-6,7-二甲氧基-2-甲基-1-(3,4,5-三甲基苄基)异喹啉氯化物(E)-4-辛烯二羧酸(2:1)
英文别名
MivacronBW-B1090U
rac-Mivacron
rac-BW-B 1090
rac-BW-B 1090U
MIVACURIUM CHLORIDE
rac Mivacurium Chloride
Mivacurium Chloride (mixture of isomers)
-1,2,3,4-Te.trahydro-2-(3-hydroxypropyl)-6,7-dimethoxy-2-methyl-1-(3,4,5-trimethoxy-benzyl)isoquinolinium chloride,(E)-4-octenedioate(2:1)
[R-[R*,R*-(E)]]2,2'-(1,8-Dioxo-4-octene-1,8-diyl)bis(oxy-3,1-propanediyl)bis[1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-(3,4,5-trimethoxyphenyl)isoquinolinium] dichloride
所属类别
原料药:骨骼肌松弛药物理化学性质
外观性状无定形固体。[α]D20-62.7°(C=1.9,水)。
比旋光度20D -62.7° (c = 1.9 in water)
储存条件Hygroscopic, -20°C Freezer, Under Inert Atmosphere
溶解度DMSO: Soluble; Water: Soluble
形态固体
颜色White to off-white
稳定性吸湿性
InChIKeyKFWHZSUNFAPZPW-NVIAPQDINA-M
常见问题列表
生物活性
Mivacurium dichloride 是一种苄基异喹啉衍生物,也是一种短效非去极化神经肌肉阻滞剂和骨骼肌松弛剂。Mivacurium dichloride 可与 nAChR 偶联,以减少或抑制乙酰胆碱对肌肉细胞末端盘的去极化作用。体外研究
Mivacurium induces LAD2 cell degranulation in a dose-dependent manner. Mivacurium stimulates intracellular Ca 2+ influx in MRGPRX2-HEK293 cells but not in NC-HEK293 cells. Mivacurium induces the release of only low levels of mediators in LAD2 cells transfected with MRGPRX2-targeted small interfering siRNA.
体内研究
Mivacurium causes pseudo-allergic reactions in C57 wild-type mice by inducing mast cells to release histamine and a decrease in body temperature.
Mivacurium is rapidly hydrolyzed in the plasma and has a short duration of action (< 10 min). Mivacurium has many advantages, such as a rapid effect, nonneurological toxicity and a lack of heart rate alteration.