107334-06-5

中文名称化合物 T28333

英文名称 PD 138312

CAS 107334-06-5

分子式 C19H23FN4O3

分子量 374.41

MOL 文件 107334-06-5.mol

107334-06-5 结构式

基本信息物理化学性质应用领域

基本信息

中文别名

化合物 T28333

英文别名

PD 138312
7-[3-(2-aminopropan-2-yl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acid

物理化学性质

沸点591.5±50.0 °C(Predicted)

密度1.442±0.06 g/cm3(Predicted)

酸度系数(pKa)6.03±0.70(Predicted)

应用领域

用途一

PD 138312 is a novel broad-spectrum 7-pyrrolidinyl fluoronaphthyridines with a cyclopropyl or a difluorophenyl substitution at the 1 positions, respectively. It has been demonstrated to have excellent in vitro activity against gram-positive organisms. This compound was evaluated for its in vivo potencies against acute systemic infections in mice and in a mouse pneumococcal pneumonia model. Most remarkable was its comparative median protective value against methicillin-resistant Staphylococcus aureus, Streptococcus pneumoniae, and Streptococcus pyogenes. PD 138312 has excellent therapeutic potential against clinically important gram-positive pathogens when the drugs are administered both orally and parenterally.