1093100-40-3
中文名称
N1-(4-氯苯基)-6-甲基-N5-[3-(9H-嘌呤-6-基)-2-吡啶]-1,5-异喹啉二胺
英文名称
B-Raf inhibitor 1
CAS
1093100-40-3
分子式
C26H19ClN8
分子量
478.94
MOL 文件
1093100-40-3.mol
1093100-40-3 结构式
基本信息
中文别名
B-RAF抑制剂(B-RAF INHIBITOR 1)N1-(4-氯苯基)-6-甲基-N5-[3-(9H-嘌呤-6-基)-2-吡啶]-1,5-异喹啉二胺
N1-(4-氯苯基)-6-甲基-N5-[3-(9H-嘌呤-6-基)-2-吡啶基]-1,5-异喹啉二胺
英文别名
CS-927or Base
Raf inhibitor 1
B-Raf inhibitor 1
BRAF inhibitor 13
B-Raf inhibitor 1 Base
B-Raf inhibitor 1, >=98%
N1-(4-Chlorophenyl)-6-methyl-N5-[3-(9H-purin-6-yl)-2-pyridinyl]-1,5-isoquinolinediamine
1-N-(4-chlorophenyl)-6-methyl-5-N-[3-(7H-purin-6-yl)pyridin-2-yl]isoquinoline-1,5-diamine
1,5-IsoquinolinediaMine, N1-(4-chlorophenyl)-6-Methyl-N5-[3-(9H-purin-6-yl)-2-pyridinyl]-
所属类别
生物化工：激动剂抑制剂物理化学性质
沸点735.4±60.0 °C(Predicted)
密度1.461±0.06 g/cm3(Predicted)
储存条件-20°C储存
溶解度≥ 47.9mg/mL in DMSO
酸度系数(pKa)8.41±0.10(Predicted)
N1-(4-氯苯基)-6-甲基-N5-[3-(9H-嘌呤-6-基)-2-吡啶]-1,5-异喹啉二胺价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/04/30 | HY-14177 | N1-(4-氯苯基)-6-甲基-N5-[3-(9H-嘌呤-6-基)-2-吡啶]-1,5-异喹啉二胺 Raf inhibitor 1 | 1093100-40-3 | 5mg | 800元 |
| 2024/04/30 | HY-14177 | N1-(4-氯苯基)-6-甲基-N5-[3-(9H-嘌呤-6-基)-2-吡啶]-1,5-异喹啉二胺 Raf inhibitor 1 | 1093100-40-3 | 10mM * 1mLin DMSO | 843元 |
| 2024/04/30 | HY-14177 | N1-(4-氯苯基)-6-甲基-N5-[3-(9H-嘌呤-6-基)-2-吡啶]-1,5-异喹啉二胺 Raf inhibitor 1 | 1093100-40-3 | 10mg | 1300元 |
常见问题列表
生物活性
Raf inhibitor 1是一种有效的 Raf 激酶抑制剂，作用于 B-RafWT, B-RafV600E, 和 C-Raf, Ki 分别为 1 nM, 1 nM, 和 0.3 nM。靶点
|
B-Raf 1 nM (Ki) |
B-Raf V600E 1 nM (Ki) |
c-Raf 0.3 nM (Ki) |
体外研究
Raf inhibitor 1 (Compound 13) inhibits A375 and HCT-116 proliferation with IC 50 s of 0.31 and 0.72 μM, respectively. Raf inhibitor 1 (Compound 13) binds to and stabilizes B-Raf in a DFG-out, inactive conformation in which the ATP pocket is partially filled by Phe595 and Gly596 from the DFG motif. Raf inhibitor 1 (Compound 13) additionally exhibits low micromolar inhibition against wild type B-Raf cell lines, which may be due to off-target kinase activities or alternatively to pan-Raf inhibition, including Raf dimers.