110115-07-6
中文名称
CALPAIN INHIBITOR II
英文名称
CALPAIN INHIBITOR II
CAS
110115-07-6
分子式
C19H35N3O4S
MDL 编号
MFCD00065506
分子量
401.56
MOL 文件
110115-07-6.mol
更新日期
2024/04/18 11:53:24
110115-07-6 结构式
物理化学性质
沸点676.5±55.0 °C(Predicted)
密度1.076±0.06 g/cm3(Predicted)
储存条件−20°C
溶解度ethanol: 20 mg/mL
酸度系数(pKa)13.32±0.46(Predicted)
形态powder
形态粉末
颜色white
颜色白色
常见问题列表
生物活性
ALLM (Calpain inhibitor II) 是钙蛋白酶 (calpain) 和组织蛋白酶 (cathepsin) 的有效抑制剂。ALLM 抑制脊髓损伤 (SCI) 后神经元死亡及改善慢性神经功能。体内研究
ALLM (Calpain inhibitor II) (0.5 mg/kg) is injected every 24 h for 5 days after SCI and inhibits the activation of calpain but not that of caspase 3. ALLM prevents this neuronal cell death.
ALLM (0.05-2.5 mg/kg; i.p.; every 24 h for 1 week) reduces motor disturbances after spinal cord injury (SCI).
| Animal Model: | Adult male Wistar rats (280-300g) (spinal cord injury model) |
| Dosage: | 0.05, 0.5, and 2.5 mg/kg |
| Administration: | Intraperitoneally; every 24 h for 1 week |
| Result: | Showed significantly better motor function. |