1116745-06-2
中文名称
DUOCARMYCIN
英文名称
DuocarMycin
CAS
1116745-06-2
分子式
C26H26ClN3O3
分子量
463.96
MOL 文件
1116745-06-2.mol
更新日期
2024/06/05 14:51:05
1116745-06-2 结构式
常见问题列表
生物活性
Duocarmycin DM free base 是一种 DNA 小沟烷基化剂 (DNA minor-groove alkylator)，是一种抗体药物结合物 (ADCs) 毒素。Duocarmycin DM free base 因特有的结构而具有抗癌活性。靶点
|
Daunorubicins/Doxorubicins
|
体外研究
The Duocarmycins and CC-1065 are members of a class of DNA minor groove, AT-sequence selective, and adenine-N3 alkylating agents, isolated from
Streptomyces sp.
that exhibit extremely potent cytotoxicity against the growth of cancer cells grown in culture.
Duocarmycin shows cytotoxicity to several human cancer cells, with IC
50
of 22, 13.8, 3.87, 15.4, and 7.31 pM for HT-29, CL1-5, Caski, EJ, and LS174T, respectively.