113658-85-8

中文名称 113658-85-8

英文名称 PCA 4230

CAS 113658-85-8

分子式 C21H24N2O7S

分子量 448.49

MOL 文件 113658-85-8.mol

113658-85-8 结构式

基本信息物理化学性质图谱信息常见问题列表

基本信息

中文别名

化合物 T13210

英文别名

PCA 4230
Trombodipine
3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,4,6-trimethyl-, 3-[2-(1,1-dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl)ethyl] 5-ethyl ester

物理化学性质

熔点144-146 °C(Solv: ethyl ether (60-29-7))

沸点623.2±65.0 °C(Predicted)

密度1.327±0.06 g/cm3(Predicted)

储存条件-20°C储存

溶解度溶于二甲基亚砜

酸度系数(pKa)3.40±0.70(Predicted)

图谱信息

113658-85-8(113658-85-8)核磁图(¹HNMR)

常见问题列表

生物活性

Trombodipine 是一种抗血栓剂。

体外研究

Trombodipine is an antithrombotic agent. Exposure to 50 μM Trombodipine reveals an important stasis of growth. The percentage of inhibition exerted by 1 μM Trombodipine on day 3, 5 and 7 of the growth curve is 22.0±4.5, 32.0±3.0 and 29.4±6.0%, respectively (P<0.05). The inhibitory effect of Trombodipine on cell proliferation is reversible and after removal of Trombodipine the proliferation of the cells is resumed. Addition of Trombodipine reduces cell number in a dose-dependent manner over a period of 4 to 6 days in culture. When compare to control cultures at the latest time points investigated, 5 μM Trombodipine decreases the number of E19P cells and human VSMCs by 25 and 21%, respectively, whereas 50 μM Trombodipine reduces E19P and human VSMC number by 85 and 74%, respectively.