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1163-36-6

中文名称 1-[(4-氯苯基)甲基]-2-(吡咯烷-1-基甲基)苯并咪唑盐酸盐
英文名称 Clemizole hydrochloride
CAS 1163-36-6
EINECS 编号 214-605-4
分子式 C19H21Cl2N3
MDL 编号 MFCD00051435
分子量 362.3
MOL 文件 1163-36-6.mol
更新日期 2024/10/10 10:59:10
1163-36-6 结构式 1163-36-6 结构式

基本信息

中文别名
1-[(4-氯苯基)甲基]-2-(吡咯烷-1-基甲基)苯并咪唑盐酸盐
盐酸氯咪唑
英文别名
1-[(4-Chlorophenyl)methyl]-2-(pyrrolidin-1-ylmethyl)benzoimidazole hydrochloride
1-P-CHLOROBENZYL-2-[1-PYRROLIDINYL]-METHYLBENZIMIDAZOLE HYDROCHLORIDE
CLEMIZOLE HCL
CLEMIZOLE HYDROCHLORIDE
LABOTEST-BB LT00453174
1-(p-chlorobenzil)-2-pirrolidil-metil-benzimidazolocloridato
1-(p-chlorobenzyl)-2-(1-pyrrolidinylmethyl)-benzimidazolmonohydrochloride
1-p-chlorobenzyl-pyrrolidyl-methylene-benzimidazolehydrochloride
allercur
allercurehydrochloride
p48
1-(4-Chlorophenyl)methyl)-2-(1-pyrrolidinylmethyl)-(1H)-benzimidazoleHCl
1-(P-CHLOROBENZYL)-2-(1-PYRROLIDINYLMETHYL)-BENZIMIDAZOL
所属类别
生物化工:激动剂抑制剂

物理化学性质

熔点239-241°
储存条件Inert atmosphere,2-8°C
溶解度在水中的溶解度为性2mg/mL,澄清(加热)
形态粉末
颜色白色至米色
水溶解性16.84mg/L at 25℃
Merck13,2368
InChIKeyDNFMJYXRIMLMBZ-UHFFFAOYSA-N
LogP1.99

安全数据

危险性符号(GHS)
GHS07
警示词警告
危险性描述H302
防范说明P301+P312+P330
危险品标志Xn
危险类别码R22
安全说明S36
WGK Germany3
RTECS号DD6730000
海关编码2933.99.8290

应用领域

用途一
用作氯咪唑青霉素等药物的中间体
1-[(4-氯苯基)甲基]-2-(吡咯烷-1-基甲基)苯并咪唑盐酸盐价格(试剂级)
报价日期产品编号产品名称CAS号包装价格
2024/08/19HY-30234A1-[(4-氯苯基)甲基]-2-(吡咯烷-1-基甲基)苯并咪唑盐酸盐
Clemizole hydrochloride
1163-36-65mg500元
2024/08/19HY-30234A1-[(4-氯苯基)甲基]-2-(吡咯烷-1-基甲基)苯并咪唑盐酸盐
Clemizole hydrochloride
1163-36-610mM * 1mLin DMSO550元
2024/08/19HY-30234A1-[(4-氯苯基)甲基]-2-(吡咯烷-1-基甲基)苯并咪唑盐酸盐
Clemizole hydrochloride
1163-36-610mg800元

常见问题列表

生物活性
Clemizole hydrochloride 是一种 H1 组胺受体 (H1 histamine receptor) 拮抗剂,抑制 HCV 复制。
靶点

IC50: 24 nM (NS4B)
H1 histamine receptor

体外研究

Clemizole hydrochloride is found to inhibit HCV RNA replication in cell culture that is mediated by its suppression of NS4B’s RNA binding, with little toxicity for the host cell. The EC 50 of Clemizole on the W55R mutant J6/JFH RNA is ~18 µM (2.25 times the EC 50 of the wild-type RNA). Clemizole is a novel inhibitor of TRPC5 channels. Clemizole efficiently blocks TRPC5 currents and Ca 2+ entry in the low micromolar range (IC 50 =1.0-1.3 µM). Clemizole exhibits a six-fold selectivity for TRPC5 over TRPC4β (IC 50 =6.4 µM), the closest structural relative of TRPC5, and an almost 10-fold selectivity over TRPC3 (IC 50 =9.1 µM) and TRPC6 (IC 50 =11.3 µM). Clemizole hydrochloride as a novel blocker of TRPC5 with a half-maximal inhibitory concentration of 1.1 µM. The concentration-response curves confirmed a concentration-dependent block of TRPC5 by Clemizole and revealed an apparent IC 50 of 1.1±0.04 µM.

体内研究

Clemizole hydrochloride has an unexpectedly short plasma half-life (measured at 0.15 hours); it is very rapidly biotransformed into a glucuronide (M14) and a dealkylated metabolite (M12) and into a variety of lesser metabolites in C57BL/6J mice.

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