116457-99-9
中文名称
1-PALMITYLTHIO-2-PALMITOYLAMIDO-1,2-DIDEOXY-SN-GLYCERO-3-PHOSPHOCHOLINE
英文名称
1-PALMITYLTHIO-2-PALMITOYLAMIDO-1,2-DIDEOXY-SN-GLYCERO-3-PHOSPHOCHOLINE
CAS
116457-99-9
分子式
C45H93N2O4PS
分子量
789.27
MOL 文件
116457-99-9.mol
116457-99-9 结构式
基本信息
英文别名
THIOETHERAMIDE PCWLWWVTPUDQTUJU-KDXMTYKHSA-N
Thioetheramide phosphorylcholine
1-PALMITYLTHIO-2-PALMITOYLAMIDO-1,2-DIDEOXY-SN-GLYCERO-3-PHOSPHOCHOLINE
1-PALMITYLTHIO-2-PALMITOYLAMINO-1,2-DIDEOXY-SN-GLYCERO-3-PHOSPHORYLCHOLINE
1-PALMITYLTHIO-2-PALMITOYLAMIDO-1,2-DIDEOXY-SN-GLYCERO-3-PHOSPHORYLCHOLINE
1,2-DIDEOXY-1-(S-HEXADECYL)THIO-2-(N-HEXADECANOYL)AMINO-SN-GLYCERYL-3-PHOSPHORYLCHOLINE
常见问题列表
概述
Thioetheramide-PC (1-Palmitylthio-2-palmitoylamido-1,2-dideoxy-sn-glycero-3-phosphorylcholine) 是一种结构改良的磷脂，可作为分泌性磷脂酶 A2 (sPLA2) 的竞争性可逆抑制剂。Thioetheramide-PC (1-Palmitylthio-2-palmitoylamido-1,2-dideoxy-sn-glycero-3-phosphorylcholine) 的 IC50 值为 2 μM，底物浓度为 0.5 mM。除了与 sPLA2 的催化位点结合外，Thioetheramide-PC (1-Palmitylthio-2-palmitoylamido-1,2-dideoxy-sn-glycero-3-phosphorylcholine) 还与该酶的激活位点结合。Thioetheramide-PC (1-Palmitylthio-2-palmitoylamido-1,2-dideoxy-sn-glycero-3-phosphorylcholine) 与激活位点的结合比与催化位点的结合更紧密。这种双重相互作用的结果 是，在低浓度下，Thioetheramide-PC (1-Palmitylthio-2-palmitoylamido-1,2-dideoxy-sn-glycero-3-phosphorylcholine) 可能会激活磷脂酶活性，而不 是抑制它。