1177356-70-5
中文名称
(+)-Blebbistatin
英文名称
(+)-Blebbistatin
CAS
1177356-70-5
分子式
C18H16N2O2
分子量
292.33
MOL 文件
1177356-70-5.mol
更新日期
2024/08/06 14:59:09
1177356-70-5 结构式
基本信息
中文别名
(+)-BLEBBISTATIN 英文别名
(+)Blebbistatin,(+) Blebbistatin(+)-Blebbistatin - CAS 1177356-70-5 - Calbiochem
4H-Pyrrolo[2,3-b]quinolin-4-one, 1,2,3,3a-tetrahydro-3a-hydroxy-6-methyl-1-phenyl-, (3aR)-
物理化学性质
沸点507.3±60.0 °C(Predicted)
密度1.31±0.1 g/cm3(Predicted)
储存条件-20C
溶解度DMF: 20 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 12.5 mg/ml
酸度系数(pKa)11.15±0.20(Predicted)
形态黄色固体
颜色yellow
应用领域
用途1
Blebbistatin blocked myosin II-dependent cell processes. It blocks cell blebbing rapidly and reversibly. Also rapidly disrupted directed cell migration and cytokinesis in vertebrate cell. It blocks both blebbing and cytokinesis at 50-100μM. A negative control for the (S)-(-)-Blebblastatin. [a]D= +110 (c= 1.21 CHCl3) (-)-1-Phenyl-1,2,3,4-tetrahydro-4-hydroxypyrrolo[2,3-b]-7-methylquinolin-4-on e