674289-55-5
中文名称
(+/-)-BLEBBISTATIN
英文名称
(+/-)-BLEBBISTATIN
CAS
674289-55-5
分子式
C18H16N2O2
分子量
292.332
MOL 文件
674289-55-5.mol
更新日期
2024/03/17 22:58:27
674289-55-5 结构式
基本信息
中文别名
(+/-)-BLEBBISTATIN 英文别名
(±)Bebbistatin(R)-(+)-BLEBBISTATIN
(+/-)-1-PHENYL-1,2,3,4-TETRAHYDRO-4-HYDROXYPYRROLO[2,3-B]-7-METHYLQUINOLIN-4-ONE
1,2,3,3a-Tetrahydro-3a-hydroxy-6-methyl-1-phenyl-4H-pyrrolo[2,3-β]quinolin-4-one
(+/-)-1-Phenyl-1,2,3,4-tetrahydro-4-hydroxypyrrolo[2,3-β]-7-methylquinolin-4-one
4H-Pyrrolo[2,3-b]quinolin-4-one, 1,2,3,3a-tetrahydro-3a-hydroxy-6-Methyl-1-phenyl-
(3aR)-1,2,3,3a-Tetrahydro-3a-hydroxy-6-methyl-1-phenyl-4H-pyrrolo[2,3-b]quinolin-4-one
(3aS)-1,2,3,3a-Tetrahydro-3a-hydroxy-6-methyl-1-phenyl-4H-pyrrolo[2,3-β]quinolin-4-one
(3aR)-1,2,3,3a-Tetrahydro-3a-hydroxy-6-methyl-1-phenyl-4H-pyrrolo[2,3-β]quinolin-4-one
(+/-)-1,2,3,3A-TETRAHYDRO-3A-HYDROXY-6-METHYL-1-PHENYL-4H-PYRROLO[2,3-B]QUINOLIN-4-ONE
所属类别
生物：生化试剂盒物理化学性质
熔点210-212°C
沸点507.3±60.0 °C(Predicted)
密度1.31±0.1 g/cm3(Predicted)
储存条件−20°C
溶解度可溶于氯仿（少量）、二氯甲烷、DMSO、乙酸乙酯、甲醇
酸度系数(pKa)11.15±0.20(Predicted)
形态亮黄色固体。
颜色黄色
CAS 数据库674289-55-5
应用领域
用途1
Blebbistatin blocked myosin II-dependent cell processes. It blocks cell blebbing rapidly and reversibly. Also rapidly disrupted directed cell migration and cytokinesis in vertebrate cell. It blocks
both blebbing and cytokinesis at 50-100碌M.常见问题列表
生物活性
Blebbistatin 是一种选择性的非肌肉肌球蛋白 II (NMII) 抑制剂，可促进角膜内皮细胞的定向迁移并加速伤口愈合，并更好地保留细胞连接完整性和屏障功能。靶点
Non-muscle myosin II (NMII)
体外研究
The therapeutic potential of targeting NMII to enhance CEC migration is investigated using bovine corneal endothelial cells (BCECs). Blebbistatin, a direct myosin motor inhibitor, promotes migration and directional persistence in CECs through decreasing actin retrograde flow and increasing lamellipodial protrusion persistence to accelerate wound healing in vitro.
体内研究
Blebbistatin (0.05 mL, 20 μM; intracameral injection; daily; for 6 days; New Zealand white rabbits) treatment promotes wound healing in rabbit corneal endothelial scraping model.
| Animal Model: | New Zealand white rabbits (16-20 weeks; 3-3.5 kg) |
| Dosage: | 0.05 mL; 20 μM |
| Administration: | Intracameral injection; daily; for 6 days |
| Result: | Resulted in significant improvement of corneal clarity and corneal edema resolution, implying the restoration of an intact corneal endothelial monolayer. |