118-08-1
中文名称
北美黄连碱
英文名称
(-)-BETA-HYDRASTINE
CAS
118-08-1
EINECS 编号
204-233-0
分子式
C21H21NO6
MDL 编号
MFCD00152561
分子量
383.39
MOL 文件
118-08-1.mol
118-08-1 结构式
基本信息
中文别名
北美黄连碱白毛茛鹼
甲種北美黃連鹼
英文别名
(1R,9S)-(-)-BETA-HYDRASTINE(1R,9S)-BETA-HYDRASTINE
(-)-BETA-HYDRASTINE
(-)-B-HYDIASTINE
HYDRASTINE
HYDRASTINE, (-)-B-
[S-(R*,S*)]-6,7-Dimethoxy-3-(5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)-1(3H)-isobenzofuranone
1(3H)-Isobenzofuranone, 6,7-dimethoxy-3-(5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)-, [S-(R*,S*)]-
6,7-Dimethoxy-3-(6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-5-yl)-2-benzofuran-1(3H)-one
l-beta-Hydrastine
l-hydrastine
Phthalide, 6,7-dimethoxy-3-(5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo(4,5-g)isoquinolin-5-yl)-
phthalide,6,7-dimethoxy-3-(5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo(4,5-g)iso
quinolin-5-yl)-
(1R,9S)-B-hydrastine free base
Hydrastinebase
Hydrastine (base and/or unspecified salts)
(1R,9S)-(-)-β-Hydrastine
(3S)-6,7-Dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-1(3H)-isobenzofuranone
[S,(-)]-6,7-Dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]isobenzofuran-1(3H)-one
物理化学性质
熔点132℃
比旋光度D20 -50° (c = 0.3 in abs alc)
沸点510.32°C (rough estimate)
密度1.339±0.06 g/cm3 (20 ºC 760 Torr)
折射率1.5614 (estimate)
储存条件−20°C
溶解度DMF: 10 mg/ml; DMSO: 10 mg/ml
酸度系数(pKa)7.8(at 25℃)
形态结晶固体
水溶解性30mg/L(20 ºC)
