118876-58-7
中文名称
二羟基喹酮
英文名称
NBQX DISODIUM SALT
CAS
118876-58-7
分子式
C12H8N4O6S
分子量
336.28
MOL 文件
118876-58-7.mol
更新日期
2024/04/24 11:30:27
118876-58-7 结构式
基本信息
中文别名
二羟基喹酮6 -硝基- 7 - 硫氨基苯并[F]喹喔啉-2,3二酮
1,2,3,4-四氢-6-硝基-2,3-二氧苯并[F]喹喔啉-7-磺钠盐水合物
英文别名
NBQXFG 9202
NBQX HYDRATE
NBQX DISODIUM
FG 9202 DISODIUM
NBQX DISODIUM SALT
NBQX disodium salt hydrate
NBQX hydrate disodium salt
FG 9202 disodium salt hydrate
NBQX DISODIUM (FG 9202) NEUROPROTECTIVE GLUTA
所属类别
生物：小分子化合物物理化学性质
熔点361°C
密度1.6027 (rough estimate)
折射率1.6000 (estimate)
储存条件0-6°C
储存条件Inert atmosphere,2-8°C
溶解度methanol: 0.25 mg/mL
溶解度溶于甲醇，溶解度为0.25mg/mL
酸度系数(pKa)7.55±0.20(Predicted)
形态solid
颜色yellow
稳定性-20℃冷冻保存
InChIKeyUQNAFPHGVPVTAL-UHFFFAOYSA-N
常见问题列表
生物活性
NBQX (FG9202, NNC 079202) 是一种具有高选择性的 AMPA receptor (AMPAR) 的竞争性拮抗剂，具有抗癫痫的作用。靶点
| Target | Value |
|
AMPAR
() |
体外研究
NBQX (FG9202) has a high affinity for AMPA and kainate binding sites with little or no affinity for the glutamate recognition site on the NMDA receptor complex.
体内研究
NBQX (FG9202; 20 mg/kg, i.p.; for 3 days) decreases seizures induced by PTZ.
NBQX is neuroprotective in a focal ischaemia model in the rat when given as an i.v. bolus dose of 30 mg/kg at the time of MCA occlusion and again at 1 h post occlusion.
| Animal Model: | Male Wistar rats that weighed 220-240 g with pentylenetetrazole (PTZ) |
| Dosage: | 20 mg/kg |
| Administration: | IP; for 3 days |
| Result: | Effectively reversed the behavioral abnormality of epileptic seizures of chronic PTZ administration (50mg/kg; i.p.; for 28 days) in rats. |