| Identification | Back Directory | [Name]
NBQX DISODIUM SALT | [CAS]
118876-58-7 | [Synonyms]
NBQX
FG 9202
NBQX HYDRATE
NBQX DISODIUM
FG 9202 DISODIUM
NBQX DISODIUM SALT
NBQX disodium salt hydrate
NBQX hydrate disodium salt
FG 9202 disodium salt hydrate
NBQX DISODIUM (FG 9202) NEUROPROTECTIVE GLUTA
2,3-Doxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline
2,3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline
6-NITRO-7-SULFAMOYLBENZO[F]QUINOXALINE-2,3-DIONE
6-NITRO-7-SULPHAMOYLBENZO(F)-QUINOXALINE-2,3-DIONE
2,3-dihydroxy-6-nitro-7-sulfamoylbenzo(f)quinoxaline
2,3-Dihydroxy-6-nitrobenzo[f]quinoxaline-7-sulfonamide
6-NITRO-7-SULPHAMOYLBENZO(F)-QUINOXALINE-2,3-DIONE 2NA
2,3-DIHYDROXY-6-NITRO-7-SULPHAMOYLBENZO(F)-QUINOXALINE
6-Nitro-7-sulfamoylbenzo[f]quinoxaline-2,3(1H,4H)-dione
2,3-DIHYDROXY-6-NITRO-7-SULPHAMOYLBENZO(F)-QUINOXALINE 2NA
6-Nitro-2,3-dioxo-2,3-dihydrobenzo[f]quinoxaline-7-sulfonamide
6-NITRO-7-SULFAMOYLBENZO[F]QUINOXALINE-2,3-DIONE, DISODIUM SALT
2,3-DIOXO-6-NITRO-1,2,3,4-TETRAHYDROBENZO[F]QUINOXALINE-7-SULFONAMIDE
1,2,3,4-TETRAHYDRO-6-NITRO-2,3-DIOXO-BENZO[F]QUINOXALINE-7-SULFONAMIDE
1,2,3,4-Tetrahydro-6-nitro-2,3-dioxo-benzo[f]quinoxaline-7-sulfonamide hydrate
1,2,3,4-TETRAHYDRO-6-NITRO-2,3-DIOXO-BENZO[F]QUINOXALINE-7-SULFONAMIDE DISODIUM
2,3-DIOXO-6-NITRO-1,2,3,4-TETRAHYDROBENZO[F]QUINOXALINE-7-SULFONAMIDE DISODIUM SALT
1,2,3,4-tetrahydro-6-nitro-2,3-dioxo-benzo[f]quinoxaline-7-sulfonamide disodium salt
FG 9202, 1,2,3,4-Tetrahydro-6-nitro-2,3-dioxo-benzo[f]quinoxaline-7-sulfonamide hydrate
1,2,3,4-Tetrahydro-6-nitro-2,3-dioxo-benzo[f]quinoxaline-7-sulfonamide disodium salt hydrate
FG 9202 hydrate disodium salt, 1,2,3,4-Tetrahydro-6-nitro-2,3-dioxo-benzo[f]quinoxaline-7-sulfonamide hydrate disodium salt | [Molecular Formula]
C12H8N4O6S | [MDL Number]
MFCD00274065 | [MOL File]
118876-58-7.mol | [Molecular Weight]
336.28 |
| Chemical Properties | Back Directory | [Appearance]
Yellow Crystalline Solid | [Melting point ]
361°C | [density ]
1.6027 (rough estimate) | [refractive index ]
1.6000 (estimate) | [storage temp. ]
0-6°C | [solubility ]
methanol: 0.25 mg/mL
| [form ]
solid
| [pka]
7.55±0.20(Predicted) | [color ]
yellow
| [Water Solubility ]
H2O: >10mg/mL | [Stability:]
Freezer at -20°C | [InChI]
InChI=1S/C12H8N4O6S/c13-23(21,22)8-3-1-2-5-9(8)7(16(19)20)4-6-10(5)15-12(18)11(17)14-6/h1-4H,(H,14,17)(H,15,18)(H2,13,21,22) | [InChIKey]
UQNAFPHGVPVTAL-UHFFFAOYSA-N | [SMILES]
N1C2=C(C3=CC=CC(S(N)(=O)=O)=C3C([N+]([O-])=O)=C2)NC(=O)C1=O |
| Hazard Information | Back Directory | [Chemical Properties]
Yellow Crystalline Solid | [Uses]
A potent and discriminating antagonist for AMPA binding sites. | [Biological Activity]
Potent, selective and competitive AMPA receptor antagonist. Neuroprotective and anticonvulsant; active in vivo . More water soluble disodium salt of NBQX (2,3-Dioxo-6-nitro-1,2,3,4-tetrahydrobenzo[f]quinoxaline-7-sulfonamide ). Also available as part of the AMPA Receptor Tocriset™ . | [Definition]
ChEBI: 2,3-Dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline is a member of naphthalenes and a sulfonic acid derivative. | [General Description]
NBQX [2,3-dihydroxy-6-nitro-7-sulphamoyl-benzo(F)quinoxaline] is a competitive antagonist, which shows high affinity to 2-amino-3-hydroxy-5-methyl-4-isoxazol propionic acid (AMPA) receptor than kainite receptor. | [Biochem/physiol Actions]
NBQX [2,3-dihydroxy-6-nitro-7-sulphamoyl-benzo(F)quinoxaline], an anticonvulsant provides protection against white matter damage in spinal cord crush injury and also protects oligodendrocyte in experimental autoimmune encephalomyelitis (EAE). However, its role in preventing inflammation in EAE is not yet clear. | [storage]
Room temperature |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
36/37/38 | [Safety Statements ]
26-36 | [WGK Germany ]
3
| [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
|
| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Sigma-Aldrich
|
| Telephone: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
|