1217049-32-5
中文名称
GYKI-47261 DIHYDROCHLORIDE
英文名称
GYKI 47261 dihydrochloride
CAS
1217049-32-5
分子式
C18H17Cl3N4
分子量
395.713
MOL 文件
1217049-32-5.mol
1217049-32-5 结构式
常见问题列表
生物活性
GYKI-47261 dihydrochloride 是一种竞争性、具有口服活性、选择性 AMPA 受体拮抗剂，IC50为 2.5 μM，具有广谱抗惊厥和神经保护作用。GYKI-47261 dihydrochloride 也是 CYP2E1 的有效诱导剂。体内研究
GYKI-47261 dihydrochloride (6 mg/kg; i.v.) shows antiischemice effect in a transient focal ischemia model, in rats. GYKI-47261 dihydrochloride (p.o.) potently mitigated the tremor induced by oxotremorine with ED50 of 16.8 mg/kg in male CD1 mice.
GYKI-47261 dihydrochloride(20 mg/kg; i.p.) reverses the dopamine depleting effect of MPTP.
| Animal Model: | Male C57 black mice, weighing 23-30 g |
| Dosage: | 20 mg/kg |
| Administration: | I.p. |
| Result: | Reversed the MPTP-induced decrease in striatal concentrations. |