| Hazard Information | Back Directory | [Uses]
GYKI 47261 Dihydrochloride is a non-competitive AMPA antagonist, used as a potential treatment for Alzheimer''s disease. | [in vivo]
GYKI-47261 dihydrochloride (6 mg/kg; i.v.) shows antiischemice effect in a transient focal ischemia model, in rats. GYKI-47261 dihydrochloride (p.o.) potently mitigated the tremor induced by oxotremorine with ED50 of 16.8 mg/kg in male CD1 mice[1].
GYKI-47261 dihydrochloride(20 mg/kg; i.p.) reverses the dopamine depleting effect of MPTP[1]. | Animal Model: | Male C57 black mice, weighing 23-30 g[1] | | Dosage: | 20 mg/kg | | Administration: | I.p. | | Result: | Reversed the MPTP-induced decrease in striatal concentrations.
|
|
|
| Company Name: |
BOC Sciences
|
| Tel: |
16314854226 |
| Website: |
www.bocsci.com |
| Company Name: |
MedChemExpress
|
| Tel: |
021-58955995 |
| Website: |
www.medchemexpress.com |
|