1256579-06-2
中文名称
6,6-二甲基-8-羟基-9-溴-11-氧代-6,11-二氢-5H-苯并[B]咔唑-3-甲腈
英文名称
9-broMo-8-hydroxy-6,6-diMethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile
CAS
1256579-06-2
分子式
C19H13BrN2O2
分子量
381.22
MOL 文件
1256579-06-2.mol
更新日期
2023/08/25 15:20:24
1256579-06-2 结构式
基本信息
中文别名
6,6-二甲基-8-羟基-9-溴-11-氧代-6,11-二氢-5H-苯并[B]咔唑-3-甲腈 英文别名
9-Bromo-6,11-dihydro-8-hydroxy-6,6-dimethyl-11-oxo-5H-benzo[b]carbazole-3-carbonitrile9-broMo-8-hydroxy-6,6-diMethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile
5H-Benzo[b]carbazole-3-carbonitrile, 9-bromo-6,11-dihydro-8-hydroxy-6,6-dimethyl-11-oxo-
9-BROMO-8-HYDROXY-6,6-DIMETHYL-11-OXO -6,11-DIHYDRO-5H-BENZO[B]CARBAZOLE-3-CARBONITRILE _1256579-06-2
物理化学性质
InChIInChI=1S/C19H13BrN2O2/c1-19(2)12-7-15(23)13(20)6-11(12)17(24)16-10-4-3-9(8-21)5-14(10)22-18(16)19/h3-7,22-23H,1-2H3
InChIKeyFTLQDYMGJVZZLI-UHFFFAOYSA-N
SMILESN1C2=C(C=CC(C#N)=C2)C2=C1C(C)(C)C1=CC(O)=C(Br)C=C1C2=O
应用领域
用途一
9-Bromo-6,11-dihydro-8-hydroxy-6,6-dimethyl-11-oxo-5H-benzo[b]carbazole-3-carbonitrile is an intermediate of Alectinib (C183360), a highly selective and potent anaplastic lymphoma kinase (ALK) inhibitor capable of blocking the resistant gatekeeper mutant, which results in reduced cell growth.