1309560-49-3
中文名称
度鲁特韦SR异构体
英文名称
Dolutegravir SR Isomer
CAS
1309560-49-3
分子式
C20H19F2N3O5
分子量
419.38
MOL 文件
1309560-49-3.mol
更新日期
2024/03/08 11:55:38
1309560-49-3 结构式
基本信息
中文别名
多替拉韦杂质5度鲁特韦杂质A
杜鲁特韦杂质6
多替拉韦杂质13
度鲁特韦杂质41
度鲁特韦对映异构体
度鲁特韦SR异构体
多替拉韦SR异构体
DOLUTEGRAVIR杂质A
英文别名
Dolutegravir SR IsomerDoultegravirr SR Isomer
Dolutegravir Impurity 41
IMpurity of Dolutegravir
Dolutegravir (S,R)-lsomer
(4S,12aR)-N-(2,4-difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide
2H-Pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide, N-[(2,4-difluorophenyl)methyl]-3,4,6,8,12,12a-hexahydro-7-hydroxy-4-methyl-6,8-dioxo-, (4S,12aR)-
Dolutegravir impurity 6/Dolutegravir SR Isomer/(4S,12aR)-N-(2,4-Difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide
所属类别
分析化学：药典标准品和杂质标准品应用领域
用途一
Dolutegravir SR Isomer is an isomeric derivative of Dolutegravir (D528800), a second generation HIV-1 integrase strand transfer inhibitor. Dolutegravir is currently in Phase III clinical trials for the treatment of HIV infection. Dolutegravir has been shown to potently inhibit HIV replication in cells such as peripheral blood mononuclear cells (PBMCs), MT-4 cells and CIP4 cells infected with a self-inactivating PHIV lentiviral vector. Dolutegravir SR Isomer.