1314217-69-0
中文名称
AZD8529 mesylate
英文名称
AZD8529 mesylate
CAS
1314217-69-0
更新日期
2023/03/20 15:41:25
分子式
C25H28F3N5O6S
分子量
583.58
MOL 文件
1314217-69-0.mol
1314217-69-0 结构式
AZD8529 mesylate价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2025/05/22 | HY-107457A | AZD-8529 mesylate | 1314217-69-0 | 1 mg | 826元 |
| 2025/05/22 | HY-107457A | AZD8529 mesylate AZD-8529 mesylate | 1314217-69-0 | 5mg | 1500元 |
| 2025/05/22 | HY-107457A | AZD8529 mesylate AZD-8529 mesylate | 1314217-69-0 | 10mM * 1mLin DMSO | 1926元 |
常见问题列表
生物活性
AZD-8529 mesylate 是一种有效的，高度选择性的，可口服的 mGluR2 正向调节剂，EC50 值为 285 nM；在 20-25 M 的浓度范围内，对 mGluR1，3，4，5，6，7 和 8 没有正向调节作用。靶点
|
mGluR2 285 nM (EC 50 ) |
体外研究
AZD-8529 mesylate potentiates the effects of glutamate at mGluR2 with an EC
50
of 195 nM .
AZD-8529 mesylate does not elicit antagonist responses on mGluRs at 25 μM.
体内研究
AZD-8529 mesylate (0.3-mg/kg, i.m.) reduces nicotine priming-induced and cue-induced reinstatement in squirrel monkeys.
AZD-8529 mesylate (30 mg/kg; i.p.) decreases the increased extracellular dopamine induced by nicotine in accumbens shell of freely-moving rats.
| Animal Model: | Sprague-Dawley rats |
| Dosage: | 10 mg/kg, 30 mg/kg |
| Administration: | Intraperitoneal injection; 2 hours before nicotine injections |
| Result: | Decreased the increased extracellular dopamine induced by nicotine (0.4 mg/kg, s.c.) in accumbens shell of freely-moving rats. |