134865-74-0

中文名称 4-P-PDOT

英文名称 4-P-PDOT

CAS 134865-74-0

分子式 C19H21NO

分子量 279.38

MOL 文件 134865-74-0.mol

更新日期 2024/06/25 17:16:00

134865-74-0 结构式

基本信息物理化学性质安全数据图谱信息 4-P-PDOT价格(试剂级) 常见问题列表

基本信息

中文别名

N-(4-苯基-1,2,3,4-四氢-2-萘基)丙酰胺

英文别名

AH-024
4-P-PDOT
4-PHENYL-2-PROPIONAMIDOTETRALIN
N-(4-phenyl-1,2,3,4-tetrahydronaphthalen-2-yl)propanamide
N-(4-Phenyl-1,2,3,4-tetrahydronaphthalen-2-yl)propionamide
Propanamide, N-(1,2,3,4-tetrahydro-4-phenyl-2-naphthalenyl)-
4-P-PDOT
4PPDOT
4P-PDOT
AH-024
4-PHENYL-2- PROPIONAMIDOTETRALIN.

物理化学性质

熔点166 °C

沸点480.1±45.0 °C(Predicted)

密度1.11±0.1 g/cm3(Predicted)

储存条件Store at RT

溶解度Soluble in DMSO > 10 mM

酸度系数(pKa)15.87±0.40(Predicted)

形态粉末

颜色白色至米色

安全数据

危险性符号(GHS) GHS hazard pictograms

GHS07

警示词警告

危险性描述H302

防范说明P264-P270-P301+P312-P330-P501

RTECS号TX1498350

海关编码2924.29.7790

图谱信息

4-P-PDOT(134865-74-0)核磁图(¹HNMR)

4-P-PDOT价格(试剂级)

报价日期	产品编号	产品名称	CAS号	包装	价格
2025/02/08	HY-100609	4-P-PDOT 4-P-PDOT	134865-74-0	1mg	394元
2025/02/08	HY-100609	4-P-PDOT 4-P-PDOT	134865-74-0	5mg	900元
2025/02/08	HY-100609	4-P-PDOT 4-P-PDOT	134865-74-0	10mM * 1mLin DMSO	1211元

常见问题列表

生物活性

4-P-PDOT 是一种有效的，选择性的和亲和性的褪黑激素受体 (MT2) 拮抗剂。4-P-PDOT 对 MT2 的选择性是 MT1 的 300 倍以上。4-P-PDOT 可显着抵消褪黑激素介导的抗氧化作用 (GSH/GSSG比，ERK 磷酸化，Nrf2 核易位，Nrf2 DNA 结合活性)。

靶点

MT2 receptor

体外研究

In CHO-mt1 cells the amidotetraline 4-P-PDOT (10 mM) has no effect on forskolin-stimulated cyclic AMP levels, either alone, or in the presence of Melatonin. In contrast, in CHO-MT2 cells, 4-P-PDOT is an agonist, producing a concentration-dependent inhibition of forskolin stimulated cyclic AMP, with a pEC ₅₀ value of 8.72 and intrinsic activity of 0.86.

Cell Viability Assay

Cell Line:	HT-29 and HeLa cells.
Concentration:	30 min.
Incubation Time:	50 µM.
Result:	Produced a negligible effect on cell viability induced by melatonin.

体内研究

4-P-PDOT (0.5-1.0 mg/kg; intravenous injection; klotho mutant mice) treatment significantly reverses antioxidant effects mediated by Melatonin. And significantly reverses the changes in the levels of these GSH-related parameters. 4-P-PDOT treatment significantly reverses the memory function of Melatonin-treated klotho mutant mice. 4-P-PDOT also counteracts Melatonin-mediated attenuation in response to the decreases in phospho-ERK expression, Nrf2 nuclear translocation, Nrf2 DNA-binding activity, and GCL mRNA expression in the hippocampi of klotho mutant mice.

Animal Model:	Klotho mutant mice treatment with Melatonin
Dosage:	0.5 mg/kg or 1.0 mg/kg
Administration:	Intravenous injection
Result:	Significantly reversed antioxidant effects mediated by Melatonin. Significantly reversed the changes in the levels of these GSH-related parameters. Significantly reversed the memory function of Melatonin-treated klotho mutant mice.