138516-31-1

中文名称 3-[1-(3-氨基丙基)-1H-吲哚-3-基]-4-(1-甲基-1H-吲哚-3-基)-1H-吡咯-2,5-二酮单乙酸盐

英文名称 Bisindolylmaleimide VIII acetate salt

CAS 138516-31-1

分子式 C24H22N4O2

分子量 398.464

MOL 文件 138516-31-1.mol

更新日期 2026/06/18 15:43:53

138516-31-1 结构式

基本信息物理化学性质安全数据图谱信息 3-[1-(3-氨基丙基)-1H-吲哚-3-基]-4-(1-甲基-1H-吲哚-3-基)-1H-吡咯-2,5-二酮单乙酸盐价格(试剂级) 常见问题列表

基本信息

中文别名

3-[1-(3-氨基丙基)-1H-吲哚-3-基]-4-(1-甲基-1H-吲哚-3-基)-1H-吡咯-2,5-二酮单乙酸盐

英文别名

Bis VIII acetate
RO 31-7549 ACETATE
BISINDOLYLMALEIMIDE VIII ACETATE SALT
BisindolylMaleiMide VIII . AcOH [Ro 31-7549]
3-[1-(3-Aminopropyl)-1H-indol-3-yl]-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione monoacetate

物理化学性质

储存条件-20°C

溶解度溶于二甲基亚砜

形态红色粉末。

颜色Brown to reddish brown

安全数据

海关编码2925199590

图谱信息

3-[1-(3-氨基丙基)-1H-吲哚-3-基]-4-(1-甲基-1H-吲哚-3-基)-1H-吡咯-2,5-二酮单乙酸盐(138516-31-1)核磁图(¹HNMR)

3-[1-(3-氨基丙基)-1H-吲哚-3-基]-4-(1-甲基-1H-吲哚-3-基)-1H-吡咯-2,5-二酮单乙酸盐价格(试剂级)

报价日期	产品编号	产品名称	CAS号	包装	价格
2026/06/05	HY-129624A	3-[1-(3-氨基丙基)-1H-吲哚-3-基]-4-(1-甲基-1H-吲哚-3-基)-1H-吡咯-2,5-二酮单乙酸盐 Bisindolylmaleimide VIII acetate	138516-31-1	1 mg	489元
2026/06/05	HY-129624A	3-[1-(3-氨基丙基)-1H-吲哚-3-基]-4-(1-甲基-1H-吲哚-3-基)-1H-吡咯-2,5-二酮单乙酸盐 Bisindolylmaleimide VIII acetate	138516-31-1	5 mg	1193元
2026/06/05	HY-129624A	3-[1-(3-氨基丙基)-1H-吲哚-3-基]-4-(1-甲基-1H-吲哚-3-基)-1H-吡咯-2,5-二酮单乙酸盐 Bisindolylmaleimide VIII acetate	138516-31-1	10 mM * 1 mL in DMSO	1203元

常见问题列表

生物活性

Bisindolylmaleimide VIII acetate (Ro 31-7549 acetate) 是一种有效的选择性蛋白激酶 C (PKC) 抑制剂，对大鼠脑 PKC 的 IC50 为 158 nM。Bisindolylmaleimide VIII acetate 对 PKC-α，PKC-βI，PKC-βII，PKC-γ，PKC-ε 的 IC50 分别为 53、195、163、213 和 175 nM。Bisindolylmaleimide VIII acetate 促进 Fas 介导的细胞凋亡 (apoptosis)，并抑制 T 细胞介导的自身免疫性疾病。

靶点

Rat Brain PKC

158 nM (IC ₅₀ )

PKC-α

53 nM (IC ₅₀ )

PKC-βI

195 nM (IC ₅₀ )

PKC-βII

163 nM (IC ₅₀ )

PKC-γ

213 nM (IC ₅₀ )

PKC-ε

175 nM (IC ₅₀ )

体外研究

Bisindolylmaleimide VIII acetate (Ro 31-7549 acetate; 5 μM; 8, 12 hours) dramatically increases TRA-8-induced cell death in time-dependent and TRA-8 dose-dependent manners.
Bisindolylmaleimide VIII acetate (5 μM; 6 hours) significantly decreases procaspase-8 at 4 h and completely disappeares at 6 h after the combined treatment with TRA-8.

Apoptosis Analysis

Cell Line:	1321N1 cells
Concentration:	5 μM
Incubation Time:	8, 12 hours
Result:	Dramatically increased TRA-8-induced cell death in time-dependent and TRA-8 dose-dependent manners.

Western Blot Analysis

Cell Line:	1321N1 cells
Concentration:	5 μM
Incubation Time:	6 hours
Result:	Significantly decreased procaspase-8 at 4 h and completely disappeared at 6 h.

体内研究

Bisindolylmaleimide VIII acetate (Ro 31-7549 acetate; 100 μg; IP; every other day for three doses) results in nearly complete tumor regression combined toTRA-8. The treatment with Bisindolylmaleimide VIII acetate alone does not induce significant tumor regression.

Animal Model:	6-8-week-old female NOD/SCID mice.
Dosage:	100 μg
Administration:	IP; every other day for three doses
Result:	Resulted in nearly complete tumor regression combined toTRA-8.