139958-16-0

中文名称化合物 T28009

英文名称 Pyridine, 3-methoxy-2,6-dimethyl-4-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methoxy]-

CAS 139958-16-0

分子式 C22H21N5O2

分子量 387.43

MOL 文件 139958-16-0.mol

139958-16-0 结构式

基本信息应用领域

基本信息

中文别名

化合物 T28009

英文别名

ME3221
ME-3221
ME 3221
Pyridine, 3-methoxy-2,6-dimethyl-4-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methoxy]-

应用领域

用途一

ME-3221 is an angiotensin type 1 receptor antagonist potentially for the treatment of hypertension. ME3221 prevents hypertensive complications in aged stroke-prone spontaneously hypertensive rats. n rats and marmosets, ME3221 antagonized angiotensin II-induced pressor responses, but did not affect bradykinin-induced depressor responses. ME3221 lowered the blood pressure in renal hypertensive rats and spontaneously hypertensive rats (SHR), and its ED25 value was 3 times that of losartan.