1420071-30-2
中文名称
无中文名称
英文名称
1H-Isoindole-1,3(2H)-dione, 5-[5-[[3-(4-broMophenyl)-2-iMino-4-oxo-5-thiazolidinylidene]Methyl]-2-furanyl]-
CAS
1420071-30-2
分子式
C22H12BrN3O4S
分子量
494.32
MOL 文件
1420071-30-2.mol
更新日期
2025/05/13 19:26:57
1420071-30-2 结构式
基本信息
中文别名
BIOYMIFI (~90%)BIOYMIFI(有异构体批次)
TRAIL受体DR5小分子激动剂(BIOYMIFI)
英文别名
CS-1259BioyMifi
(DR5 ACTIVATOR)
Bioymifi (~90%)
Bioymifi >=98% (HPLC)
Bioymifi, 1420071-30-2
Bioymifi, DR5 Activator
Bioymifi,DR5 Activator, >95%
(Z)-5-(5-[(3-[4-Bromophenyl]-2-imino-4-oxothiazolidin-5-ylidene)methyl]furan-2-yl)isoindoline-1,3-dione
(E)-5-(5-((3-(4-bromophenyl)-2-imino-4-oxothiazolidin-5-ylidene)methyl)furan-2-yl)isoindoline-1,3-dione
所属类别
生物化工：激动剂抑制剂物理化学性质
密度1.75±0.1 g/cm3(Predicted)
储存条件2-8°C
溶解度DMSO：可溶，2mg/mL，澄清（加热）
酸度系数(pKa)9.62±0.20(Predicted)
形态粉末
颜色orange to dark orange red
(Z)-5-(5-((3-(4-溴苯基)-2-亚氨基-4-氧代噻唑烷-5-亚基)甲基)呋喃-2-基)异吲哚啉-1,3-二酮价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2025/02/08 | HY-18377 | BIOYMIFI Bioymifi | 1420071-30-2 | 5mg | 720元 |
| 2025/02/08 | HY-18377 | BIOYMIFI Bioymifi | 1420071-30-2 | 10mM * 1mLin DMSO | 792元 |
| 2025/02/08 | HY-18377 | BIOYMIFI Bioymifi | 1420071-30-2 | 10mg | 1200元 |
常见问题列表
生物活性
Bioymifi 是一种有效的 TRAIL 受体 DR5 激活剂，与DR5的胞外结构域 (ECD) 结合，Kd 为 1.2 μM，Bioymifi 可作为单一的诱导剂诱导 DR5 的聚集，导致细胞凋亡。体外研究
Bioymifi (3-10 µM) induces caspase-8-dependent apoptosis. At a 10-μM concentration, Bioymifi induces processing of caspase-3 into smaller fragments.
Bioymifi induces apoptosis via death receptor DR5. Bioymifi promotes DR5 aggregation and activation. Bioymifi shares the same DR5-dependent extrinsic apoptotic pathway with TRAIL. Binding of bioymifi to DR5 recruits FADD, which in turn engages with the apical caspase-8 to form death-inducing signaling complex (DISC) Bioymifi (3-10 µM) induces caspase-8-dependent apoptosis. At a 10-μM concentration, Bioymifi induces processing of caspase-3 into smaller fragments.