1423381-07-0
中文名称
Pep2m, myristoylated
英文名称
Pep2m, myristoylated
CAS
1423381-07-0
分子式
C63H118N18O14S
分子量
1383.81
MOL 文件
1423381-07-0.mol
1423381-07-0 结构式
常见问题列表
生物活性
Pep2m, myristoylated (Myr-Pep2m) 是一种细胞通透性肽。Pep2m, myristoylated (Myr-Pep2m) 能破坏蛋白激酶 ζ (PKMζ) 下游靶点 NSF/GluR2 相互作用。PKMζ 具有自主活性的 PKC 同工酶。靶点
NSF/GluR2 interactions
体外研究
Pep2m, myristoylated (10 μM) blocks PKMζ-mediated AMPA receptor (AMPAR) potentiation.
Pep2m, myristoylated does not block the increase of PKMζ in the hippocampal slices during long-term potentiation (LTP) maintenance, indicating that blocking NSF/GluR2 interactions do not prevent the induction of PKMζ synthesis.
Pep2m, myristoylated blocks NSF/GluR2-mediated AMPAR trafficking, and reverses persistent potentiation at both the strongly stimulates synapses and the weakly stimulats synapses that underwent synaptic tagging and capture.
体内研究
Pep2m, myristoylated (10 µg) results in an increase in paw withdrawal thresholds (PWTs) on nociceptive responses in the formalin test.
| Animal Model: | Female and male Long-Evans hooded rats (8 weeks) |
| Dosage: | 10 µg (in 20 µL) |
| Administration: | Intrathecal injection |
| Result: | Resulted in an increase in PWTs, in both male and female rats at various time points tested. |