146670-40-8
中文名称
SR 11237
英文名称
SR 11237
CAS
146670-40-8
分子式
C24H28O4
分子量
380.48
MOL 文件
146670-40-8.mol
更新日期
2025/05/07 13:48:08
146670-40-8 结构式
基本信息
中文别名
化合物SR11237化合物 T23383
英文别名
BMS649SR 11237
BMS 188649
4-(2-(5,5,8,8-tetraMethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-1,3-dioxolan-2-yl)benzoic acid
4-[2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1,3-dioxolan-2-yl]-benzoicacid
Benzoic acid, 4-[2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1,3-dioxolan-2-yl]-
所属类别
生物化工：抑制剂SR 11237价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2025/02/08 | HY-107413 | SR11237 | 146670-40-8 | 1 mg | 800元 |
| 2025/02/08 | HY-107413 | SR 11237 SR11237 | 146670-40-8 | 5mg | 1900元 |
| 2025/02/08 | HY-107413 | SR 11237 SR11237 | 146670-40-8 | 10 mg | 2900元 |
常见问题列表
生物活性
SR11237 (BMS-649) 是一种视黄醇 X 受体 (RXR) 选择性激动剂，没有任何 RAR 活性。SR11237可导致 RXR/RXR 同型二聚体形成并激活含有 RXR 反应元件的报告基因。体外研究
Using nuclear receptor co-transfection assays in COS-1 cells, that SR11237 is effective at transactivating a chloramphenicol acetyltransferase reporter gene through RXRs but not retinoic acid receptors.
体内研究
SR11237 (BMS-649) (25 mg/kg; i.p.; daily from post-natal days 5 to 15) causes irregular ossification and premature closure of the growth plate.
| Animal Model: | Sprague-Dawley rats |
| Dosage: | 25 mg/kg |
| Administration: | I.p.; daily from post-natal days 5 to 15 |
| Result: | Caused disturbed ossification and bone morphology in rats, including premature growth plate closure and infiltration of ossified tissue through the central epiphysis. |