1482-50-4
中文名称
11-BETA,17-ALPHA,21-TRIHYDROXY-5-BETA-PREGNANE-3,20-DIONE
英文名称
11-BETA,17-ALPHA,21-TRIHYDROXY-5-BETA-PREGNANE-3,20-DIONE
CAS
1482-50-4
分子式
C21H32O5
分子量
364.48
MOL 文件
1482-50-4.mol
更新日期
2025/10/28 16:38:13
1482-50-4 结构式
基本信息
英文别名
dihydrocortisol5B-Dihydrocortisol
52-Dihydrocortisol
5β-Dihydrocortisol
5-BETA-DIHYDROCORTISOL
21-Di[methylenebis(oxy)] 5&alpha
5B-pregnane-11B-17A-21-triol-3-20-dione
5β-Pregnane-11β,17α,21-triol-3,20-dione
5-BETA-PREGNAN-11-BETA, 17,21-TRIOL-3,20-DIONE
5BETA-PREGNAN-11BETA,17ALPHA,21-TRIOL-3,20-DIONE
物理化学性质
熔点>173°C (dec.)
沸点544.5±50.0 °C(Predicted)
密度1.249±0.06 g/cm3(Predicted)
储存条件Refrigerator
溶解度可溶于DMSO（少许）、甲醇（少许）
酸度系数(pKa)12.50±0.70(Predicted)
形态固体
颜色白色至灰白色
11-BETA,17-ALPHA,21-TRIHYDROXY-5-BETA-PREGNANE-3,20-DIONE价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2025/05/22 | HY-N3995 | 11-BETA,17-ALPHA,21-TRIHYDROXY-5-BETA-PREGNANE-3,20-DIONE 5β-Dihydrocortisol | 1482-50-4 | 5mg | 2215元 |
| 2025/05/22 | HY-N3995 | 11-BETA,17-ALPHA,21-TRIHYDROXY-5-BETA-PREGNANE-3,20-DIONE 5β-Dihydrocortisol | 1482-50-4 | 10mg | 3550元 |
| 2025/02/08 | HY-N3995 | 11-BETA,17-ALPHA,21-TRIHYDROXY-5-BETA-PREGNANE-3,20-DIONE 5β-Dihydrocortisol | 1482-50-4 | 10mM * 1mLin DMSO | 3080元 |
常见问题列表
生物活性
5β-Dihydrocortisol，氢化可的松 (Cortisol) 的代谢产物，是潜在的盐皮质激素。5β-Dihydrocortisol 可以增强糖皮质激素的活性以提高眼压。5β-Dihydrocortisol 可引起乳腺癌细胞凋亡。体外研究
5β-Dihydrocortisol (10-100 μM; 48 h) inhibits the viability of MCF-7 cells, with an IC
50
of 27.59 μM.
5β-Dihydrocortisol (14 μM; 24 h) induces 35.6% early apoptosis and 2.5% late apoptosis in MCF-7 cells.
5β-Dihydrocortisol (1-10 μM; 48 h) quenches the intrinsic fluorescence of human serum albumin (HAS) with a maximum emission peak at 360 nm, with no shift in fluorescence peak.
Cell Viability Assay
| Cell Line: | MCF-7 and HEK 293 cells |
| Concentration: | 10, 20, 40, 60, 80, 100 μM |
| Incubation Time: | 48 hours |
| Result: |
Inhibited the viability of MCF-7 cells in a dose-dependent manner.
No toxicity in terms of cell viability was observed with HEK293 cell line. |
Apoptosis Analysis
| Cell Line: | MCF-7 cells |
| Concentration: | 14 μM |
| Incubation Time: | 24 hours |
| Result: | Induced 35.6% and 2.5% of early and late apoptosis. |
体内研究
5β-Dihydrocortisol (0.1-1.0%; 18 d) potentiates the action of topically applied Dexamethasone (0.06%) in raising the intraocular pressure (IOP) in young rabbits.