150915-41-6
150915-41-6 结构式
基本信息
(3AS,7AR)-2-[4-[4-(1,2-苯并噻唑-3-基)哌嗪-1-基]丁基]-3A,4,5,6,7,7A-六氢异吲哚-1,3-二酮
PEROSPIRONE
PEROSPIRONE HCL
[14C]-Perospirone
PerospironeQ: What is Perospirone Q: What is the CAS Number of Perospirone
cis-N-[4-[4-(1,2-Benzisothiazol-3-yl)-1-piperazinyl]butyl]-1,2-cyclohexanedicarboximide
(1R,2S)-N-[4-[4-(1,2-Benzisothiazole-3-yl)-1-piperazinyl]butyl]cyclohexane-1,2-dicarbimide
1H-Isoindole-1,3(2H)-dione, 2-[4-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]butyl]hexahydro-, cis-
(3aα,7aα)-2-[4-[4-(1,2-Benzisothiazol-3-yl)-1-piperazinyl]butyl]hexahydro-1H-isoindole-1,3(2H)-dione
(3aS,7aR)-2-[4-[4-(1,2-Benzothiazol-3-Yl)Piperazin-1-Yl]Butyl]-3a,4,5,6,7,7a-Hexahydroisoindole-1,3-Dione
物理化学性质
常见问题列表
|
5-HT 2A Receptor 0.6 nM (Ki) |
Dopamine D 2 1.4 nM (Ki) |
5-HT 1A Receptor 2.9 nM (Ki) |
5-HT 1 Receptor 18 nM (Ki) |
Dopamine D 1 41 nM (Ki) |
Perospirone (SM-9018 free base) possesses moderate affinities for α 1 , 5-HT 1 , and D 1 receptors (K i =17, 18 and 41 nM, respectively) .
Perospirone (SM-9018 free base; 1.0-10.0 mg/kg/day; orally; for 14 consecutive days) significantly attenuates PCP-induced cognitive deficits in mice in a dose-dependent manner.
| Animal Model: | Male ICR mice (6 weeks old) weighing 25-30 g |
| Dosage: | 1.0, 3.0 or 10.0 mg/kg |
| Administration: | Orally; daily; for 14 consecutive days |
| Result: | Significantly attenuated PCP-induced cognitive deficits in mice in a dose-dependent manner. |