153566-55-3
英文名称
1,8-Naphthyridine-3-carboxylic acid, 7-[3-(1-amino-1-methylethyl)-1-pyrrolidinyl]-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-, hydrochloride (5:6), (R)- (9CI)
CAS
153566-55-3
分子式
C19H24ClFN4O3
分子量
410.87
MOL 文件
153566-55-3.mol
153566-55-3 结构式
基本信息
英文别名
1,8-Naphthyridine-3-carboxylic acid, 7-[3-(1-amino-1-methylethyl)-1-pyrrolidinyl]-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-, hydrochloride (5:6), (R)- (9CI)应用领域
用途一
PD138312 HCl is a novel broad-spectrum 7-pyrrolidinyl fluoronaphthyridines with a cyclopropyl or a difluorophenyl substitution at the 1 positions, respectively. It has been demonstrated to have excellent in vitro activity against gram-positive organisms. This compound was evaluated for its in vivo potencies against acute systemic infections in mice and in a mouse pneumococcal pneumonia model. Most remarkable was its comparative median protective value against methicillin-resistant Staphylococcus aureus, Streptococcus pneumoniae, and Streptococcus pyogenes. PD 138312 has excellent therapeutic potential against clinically important gram-positive pathogens when the drugs are administered both orally and parenterally.