| Identification | Back Directory | [Name]
1,8-Naphthyridine-3-carboxylic acid, 7-[3-(1-amino-1-methylethyl)-1-pyrrolidinyl]-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-, hydrochloride (5:6), (R)- (9CI) | [CAS]
153566-55-3 | [Synonyms]
1,8-Naphthyridine-3-carboxylic acid, 7-[3-(1-amino-1-methylethyl)-1-pyrrolidinyl]-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-, hydrochloride (5:6), (R)- (9CI) | [Molecular Formula]
C19H24ClFN4O3 | [MOL File]
153566-55-3.mol | [Molecular Weight]
410.87 |
| Hazard Information | Back Directory | [Description]
PD138312 HCl is a novel broad-spectrum 7-pyrrolidinyl fluoronaphthyridines with a cyclopropyl or a difluorophenyl substitution at the 1 positions, respectively. It has been demonstrated to have excellent in vitro activity against gram-positive organisms. This compound was evaluated for its in vivo potencies against acute systemic infections in mice and in a mouse pneumococcal pneumonia model. Most remarkable was its comparative median protective value against methicillin-resistant Staphylococcus aureus, Streptococcus pneumoniae, and Streptococcus pyogenes. PD 138312 has excellent therapeutic potential against clinically important gram-positive pathogens when the drugs are administered both orally and parenterally. |
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