159752-10-0
159752-10-0 结构式
基本信息
伊布莫仑甲磺酸盐
伊布莫伦甲磺酸盐
MK-677 马来酸盐
MK677 POWDER
伊布莫仑甲磺酸盐(MK-677)
Ibutamoren mesilate
MK677 MK 677 IBUTAMOREN
MK677（Ibutamoren Mesylate）
nicotinamide mononucleotide powder
MK-677
CRESCENDO
MK 0677
MK-0677
MK0677
MK677
MK 677
MK-667
CS-1402
MK-0667
nutrobal
物理化学性质
常见问题列表
伊布莫仑甲磺酸盐是一种药物，它作为一个强有力的，口服有效的促生长激素分泌，模仿gh刺激内源性激素的作用。
伊布莫仑甲磺酸盐已被证实能增加的释放,并产生持续增加等离子体水平的一些激素包括gh和胰岛素样生长因子1(igf - 1),但不影响皮质醇水平。目前正在开发的潜在治疗减少了这些激素的水平,比如在儿童或老年人与生长激素缺乏症,和人类研究显示增加肌肉和骨矿物质密度,使之成为一个有前途治疗虚弱的老人。它也改变体内脂肪的代谢,所以可能在肥胖的治疗中的应用。
Ibutamoren mesylate (MK-0667, L-163191)是一种口服有效的的生长激素（GH)促分泌素，是一种有效的非肽饥饿素受体激动剂。
Ibutamoren mesylate (5 mg/kg/day) results in a statistically significant increases body weight gain and increases serum IGF-1 and GH levels in dogs. Ibutamoren mesylate results in no significant increase in CSF IGF-1 or GH levels on days 7 or 15 of the study. Pretreating mice with GH blocks activation of these neurons by Ibutamoren mesylate (50 μg, i.p.). In the knockout mice, both GH and octreotide fail to inhibit Ibutamoren mesylate activation of arcuate neurons. Chronic oral administration of MK-0677 is associated with significant increases in GH and IGF-I levels that are maintained for the duration of the treatment. The GH profile following MK-0677 administration consists of episodic increases above control. MK-0677 significantly increases peak GH concentrations after oral administration. MK-0677 is a potent GH secretagogue that induces an immediate, large, long lasting increase in GH levels when administered orally or i.v.