16616-39-0
中文名称
1-(3-硝基苯基)-3-苯基丙-2-炔-1-酮
英文名称
1-(3-nitrophenyl)-3-phenyl-2-propyn-1-one
CAS
16616-39-0
分子式
C15H9NO3
分子量
251.24
MOL 文件
16616-39-0.mol
更新日期
2024/05/24 11:46:38
16616-39-0 结构式
基本信息
中文别名
化合物MLS0005322231-(3-硝基苯基)-3-苯基丙-2-炔-1-酮
英文别名
MLS-532223MLS000532223
1-(3-nitrophenyl)-3-phenyl-2-propyn-1-one
1-(3-Nitrophenyl)-3-phenylprop-2-yn-1-one
2-Propyn-1-one, 1-(3-nitrophenyl)-3-phenyl-
GTPases,Inhibitor,MLS-000532223,MLS 000532223,MLS000532223,Rab,cytoskeleton,actin,Rho GTPases,Ras,inhibit
物理化学性质
熔点120-121 °C
沸点419.6±47.0 °C(Predicted)
密度1.31±0.1 g/cm3(Predicted)
储存条件RT (des.)
溶解度溶于DMSO（高达20mg/ml）。
形态固体
颜色米色
稳定性DMSO溶液可在-20°下稳定储存2个月。
常见问题列表
生物活性
MLS000532223 是一种 Rho family GTPases 的高亲和力的选择性抑制剂，EC50值为16 μM至120 μM。靶点
| Target | Value |
|
Rho
(Cell-free assay) | 16 μM(EC50) |
体外研究
MLS000532223 prevents GTP binding to several GTPases in a dose-dependent manner.
MLS000532223 modulates Rho-family GTP-binding kinetics.
MLS000532223 is active in cell-based assays and inhibits EGF-stimulated Rac 1 activation.
MLS000532223 inhibits actin rearrangements and changes in cell morphology that are downstream of Rho family GTPase activation.
MLS000532223 (10 μM) modulates actin remodeling in mast cells.
MLS000532223 (10 μM) inhibits ligand-stimulated β-hexosaminidase secretion of RBL cells.