166882-70-8

中文名称 166882-70-8

英文名称 2H-Indol-2-one,1,3-dihydro-1-methyl-5-[[4-[(2S,4R)-tetrahydro-4-hydroxy-2-methyl-2H-pyran-4-yl]-2-thienyl]thio]-

CAS 166882-70-8

分子式 C19H21NO3S2

分子量 375.5

MOL 文件 166882-70-8.mol

166882-70-8 结构式

基本信息物理化学性质常见问题列表

基本信息

中文别名

化合物 T10438

英文别名

ZD 4407
AZD 4407
2H-Indol-2-one,1,3-dihydro-1-methyl-5-[[4-[(2S,4R)-tetrahydro-4-hydroxy-2-methyl-2H-pyran-4-yl]-2-thienyl]thio]-

物理化学性质

沸点665.6±55.0 °C(Predicted)

密度1.38±0.1 g/cm3(Predicted)

储存条件-20°C储存

溶解度溶于二甲基亚砜

酸度系数(pKa)13.68±0.40(Predicted)

常见问题列表

生物活性

AZD 4407 是一种有效的 5-脂氧合酶 (5-lipoxygenase) 抑制剂。

靶点

5-Lipoxygenase

体外研究

In view of the powerful spasmogenic actions of leukotrienes in vascular and bronchial tissue, drugs which block their biosynthesis by inhibiting 5-lipoxygenase may have therapeutic potential in a variety of inflammatory conditions including inflammatory arthropothies, asthma, psoriasis, and inflammatory bowel disease. One such compound is AZD 4407 (ZD4407).