1684-40-8
1684-40-8 结构式
基本信息
塔克林
盐酸单满吖啶氨
盐酸他克林
1,2,3,4-TETRAHYDRO-9-ACRIDINAMINE, MONOHYDROCHLORIDE
9-AMINO-1,2,3,4-TETRAHYDROACRIDINE HYDROCHLORIDE
COGNEX
ROMOTAL
TACRINE
TACRINE HCL
TACRINE HYDROCHLORIDE
1,2,3,4-tetrahydro-9-acridinaminmonohydrochloride
1,2,3,4-tetrahydro-9-aminoacridinehydrochloride
1,2,3,4-tetrahydro-9-amino-acridinmonohydrochloride
9-amino-1,2,3,4-tetrahydro-acridinhydrochloride
ci970
hydroaminacrine
tacrinhydrochloride
tenakrin
tetrahydroaminacrin
1,2,3,4-tetrahydroacridin-9-amine monohydrochloride
9-AMINO-1,2,3,4-TETRAHYDROACRIDINEHYDROC HLORIDE HY
9-AMINO-1,2,3,4-TETRAHYDROACRIDINE HYDRO -CHLORIDE (TACRINE, TH
物理化学性质
安全数据
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/01/25 | HY-111338 | 四氢氨基吖啶 Tacrine | 1684-40-8 | 5 mg | 800元 |
| 2024/01/25 | HY-B1488 | 四氢氨基吖啶 Tacrine hydrochloride | 1684-40-8 | 100mg | 600元 |
| 2024/01/25 | HY-111338 | 四氢氨基吖啶 Tacrine | 1684-40-8 | 10 mg | 1200元 |
常见问题列表
| Target | Value |
|
BChE
(Cell-free assay) | 25.6 nM |
|
AChE
(Cell-free assay) | 31 nM |
Tacrine (12.5-37.5 nM) inhibits venom acetylcholinesterase as well as human serum butyrylcholinesterase in a concentration-dependent manner.
Tacrine reduces the neurotoxicity induced by the activation of the NMDARs in murine cortical neuronal cultures with an IC
50
of ~500 μM.
Tacrine inhibits the NMDAR responses in a concentration-dependent manner with an IC
50
of ~190 μM at -60 mV.
Tacrine (20-40 μmol/kg; s.c.) disrupts retention of learning in 17- and 30-day old mice in passive avoidance, and while the low dose of tacrine treatment (5 μmol/kg; s.c.) improves retention in 17-day old mice.
Tacrine (0.1-0.4 mg/mL; i.p. for 7 d) inhibits the expression of AChE, but does not significantly improve the protection of the retina function and morphology in mice.