1789738-04-0
中文名称
AMY-101 TFA
英文名称
Cp40 TFA
CAS
1789738-04-0
分子式
C85H118F3N23O20S2
分子量
1903.14
MOL 文件
1789738-04-0.mol
1789738-04-0 结构式
AMY-101 TFA价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2025/02/08 | HY-P1717A | AMY-101 TFA | 1789738-04-0 | 1mg | 1200元 |
| 2025/02/08 | HY-P1717A | AMY-101 TFA | 1789738-04-0 | 5mg | 3200元 |
| 2025/02/08 | HY-P1717A | AMY-101 TFA | 1789738-04-0 | 10mg | 5000元 |
常见问题列表
生物活性
AMY-101 TFA (Cp40 TFA) 是补体 C3 的肽类抑制剂 (KD = 0.5 nM)，可抑制非人类灵长类动物自然发生的牙周炎。AMY-101 TFA (Cp40 TFA) 在 COVID-19 重症肺炎合并全身超炎症模型中具有良好的抗炎活性。靶点
KD: 0.5 nM (C3).
体内研究
AMY-101 can improve the periodontal condition of NHPs with natural chronic periodontitis.
AMY-101 can induce a long-lasting anti-inflammatory effect.
AMY-101 (4 mg/kg bodyweight, subcutaneous injection. once per 24 hr for a total of 28 days) causes a significant and long-lasting reduction in PPD, an index that measures tissue destruction.
| Animal Model: | Fifteen adult male cynomolgus monkeys (Macaca fascicularis) (7-15 years old; 5.0-7.6 kg body weight). |
| Dosage: | 0.1 mg/site; 50 μL of 2 mg/mL solution. |
| Administration: | Injected locally. (Either three times per week or once a week for 6 weeks followed by a 6-week follow-up period without treatment.) |
| Result: | Does not cause irritation in healthy gingiva. |