18660-81-6
中文名称
河豚毒素鹼
英文名称
TETRODOTOXIN CITRATE
CAS
18660-81-6
分子式
C17H25N3O15
分子量
511.39
MOL 文件
18660-81-6.mol
18660-81-6 结构式
基本信息
中文别名
河豚毒素鹼河豚毒素柠檬酸酯盐
英文别名
TETRODOTOXINTETRODOTOXIN CITRATE
citratodetetrodotoxina
tetrodotoxin,citrate(1:1)(salt)
Tetrodotoxin(TTX), with citrate
Citrato de tetrodotoxina [spanish]
Tetrodotoxin, 2-hydroxy-1,2,3-propanetricarboxylate (1:1) (salt) (9ci)
Octahydro-12-(hydroxymethyl)-2-imino-5,9:7,10a-dimethano-10aH-[1,3]dioxocino[6,5-d]pyrimidine-4,7,10,11,12-pentolcitrat
OCTAHYDRO-12-(HYDROXYMETHYL)-2-IMINO-5,9:7,10A-DIMETHANO-10AH-[1,3]DIOXOCINO[6,5-D]PYRIMIDINE-4,7,10,11,12-PENTOL CITRATE
(5R,6R,7S,9R,11R,12R,13S,14S)-3-amino-14-(hydroxymethyl)-8,10-dioxa-2,4-diazatetracyclo[7.3.1.1~7,11~.0~1,6~]tetradec-3-ene-5,9,12,13,14-pentol 2-hydroxypropane-1,2,3-tricarboxylate (1:1) (non-preferred name)
物理化学性质
储存条件Desiccate at -20°C
溶解度Citrate Buffer (pH 4.8): 30 mg/ml (100 mM)
酸度系数(pKa)8.76(at 25℃)
形态固体
水溶解性溶于水至100mM
稳定性Unstable in Acidic solution, Unstable In Acidic Solution
安全数据
警示词危险
危险性描述H300-H330-H310
危险品标志T+
危险类别码26/27/28
安全说明22-36/37/39-45
RTECS号IO1450000
毒性A toxin
contained in the ovary and liver of puffer fish, in the eggs of
the California newt and in some other animals. It is used as a
chemical tool for the study of ion channels. The s.c. LD50 in
mice is 10 mg/kg. It is a toxicant of nerve and muscle by
blocking sodium channels, this action causing nerve and muscle paralysis. Symptoms include weakening of voluntary muscles, respiratory failure from paralysis of the diaphragm and
hypotension. There is no antidote. Therapy involves artificial
respiration.